The state of starch/hydroxyapatite composite scaffold in bone tissue engineering with consideration for dielectric measurement as an alternative characterization technique

Hydroxyapatite (HA) has been widely used as a scaffold in tissue engineering. HA possesses high mechanical stress and exhibits particularly excellent biocompatibility owing to its similarity to natural bone. Nonetheless, this ceramic scaffold has limited applications due to its apparent brittleness....

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Bibliographic Details
Published in:Materials
Main Author: Mohd Roslan M.R.; Mohd Kamal N.L.; Abdul Khalid M.F.; Mohd Nasir N.F.; Cheng E.M.; Beh C.Y.; Tan J.S.; Mohamed M.S.
Format: Review
Language:English
Published: MDPI AG 2021
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104725074&doi=10.3390%2fma14081960&partnerID=40&md5=35b5ed6161192b3667447a3038d4145a
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Summary:Hydroxyapatite (HA) has been widely used as a scaffold in tissue engineering. HA possesses high mechanical stress and exhibits particularly excellent biocompatibility owing to its similarity to natural bone. Nonetheless, this ceramic scaffold has limited applications due to its apparent brittleness. Therefore, this had presented some difficulties when shaping implants out of HA and for sustaining a high mechanical load. Fortunately, these drawbacks can be improved by combining HA with other biomaterials. Starch was heavily considered for biomedical device applications in favor of its low cost, wide availability, and biocompatibility properties that complement HA. This review provides an insight into starch/HA composites used in the fabrication of bone tissue scaffolds and numerous factors that influence the scaffold properties. Moreover, an alternative characterization of scaffolds via dielectric and free space measurement as a potential contactless and nondestructive measurement method is also highlighted. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ISSN:19961944
DOI:10.3390/ma14081960