Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats

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Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats

We have synthesized new hybrid class of indole bearing sulfonamide scaffolds (1–17) as α-glucosidase inhibitors. All scaffolds were found to be active except scaffold 17 and exhibited IC50 values ranging from 1.60 to 51.20 µM in comparison with standard acarbose (IC50 = 42.45 µM). Among the synthesi...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Taha M.; Imran S.; Salahuddin M.; Iqbal N.; Rahim F.; Uddin N.; Shehzad A.; Khalid Farooq R.; Alomari M.; Mohammed Khan K.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2021
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102849446&doi=10.1016%2fj.bioorg.2021.104808&partnerID=40&md5=3378c9754bd5cd1f09b1097f773a98af

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