Transient prenatal ruxolitinib treatment suppresses astrogenesis during development and improves learning and memory in adult mice

QR Code

Transient prenatal ruxolitinib treatment suppresses astrogenesis during development and improves learning and memory in adult mice

Ruxolitinib is the first janus kinase 1 (JAK1) and JAK2 inhibitor that was approved by the United States Food and Drug Administration (FDA) agency for the treatment of myeloproliferative neoplasms. The drug targets the JAK/STAT signalling pathway, which is critical in regulating the gliogenesis proc...

Full description

Bibliographic Details
Published in:	Scientific Reports
Main Author:	Lee H.-C.; Hamzah H.; Leong M.P.-Y.; Md Yusof H.; Habib O.; Zainal Abidin S.; Seth E.A.; Lim S.-M.; Vidyadaran S.; Mohd Moklas M.A.; Abdullah M.A.; Nordin N.; Hassan Z.; Cheah P.-S.; Ling K.-H.
Format:	Article
Language:	English
Published:	Nature Research 2021
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101446415&doi=10.1038%2fs41598-021-83222-z&partnerID=40&md5=bd59ec493f7c72b6d7626540688eb66f

Similar Items

Mahanimbine improved aging-related memory deficits in mice through enhanced cholinergic transmission and suppressed oxidative stress, amyloid levels, and neuroinflammation
by: Mani V.; Azahan N.S.M.; Ramasamy K.; Lim S.M.; Majeed A.B.A.
Published: (2022)

Chronic restraint stress impairs sociability but not social recognition and spatial memory in C57BL/6J mice
by: Zain M.A.; Pandy V.; Majeed A.B.A.; Wong W.F.; Mohamed Z.
Published: (2019)

Phencyclidine dose optimisation for induction of spatial learning and memory deficits related to schizophrenia in c57bl/6 mice
by: Zain M.A.; Rouhollahi E.; Pandy V.; Mani V.; Majeed A.B.A.; Wong W.F.; Mohamed Z.
Published: (2018)

Lactobacilli-fermented cow's milk attenuated lipopolysaccharide-induced neuroinflammation and memory impairment in vitro and in vivo
by: Musa N.H.; Mani V.; Lim S.M.; Vidyadaran S.; Abdul Majeed A.B.; Ramasamy K.
Published: (2017)

Experimental study on transient response of fuel cell
by: Jeman A.A.J.; Hannoon N.M.S.; Hidayat N.; Adam M.M.H.; Musirin I.; Vijayakumar V.
Published: (2019)

Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives
by: Mohd Aluwi M.F.F.; Rullah K.; Haque M.A.; Yamin B.M.; Ahmad W.; Amjad M.W.; Leong S.W.; Fahmizar N.A.; Jalil J.; Abas F.; Ismail N.H.; Jantan I.; Lam K.W.
Published: (2017)

Classification of transient in power system using support vector machine
by: Harnzah N.; Anuwar F.H.; Zakaria Z.; Tahir N.Md.
Published: (2009)

Mak Yong’s Performing Art: A Collection Analysis of Malaysia Institutional Memory
by: Khan M.P.; Hussin A.A.; Daud K.A.M.; Nordin N.M.
Published: (2022)

Distinguishing relaxation dynamics in transiently crosslinked polymeric networks
by: Tan C.S.Y.; Agmon G.; Liu J.; Hoogland D.; Janeček E.-R.; Appel E.A.; Scherman O.A.
Published: (2017)

Liver dysfunction in adults with COVID-19 infection: A longitudinal study with transient elastography evaluation
by: Rajaram R.B.; Jayaraman T.; Khoo X.-H.; Saravanaa N.; Kukreja A.; Johari B.M.; Fareeda Muhammad Gowdh N.; Lee W.-K.; Sooi C.-Y.; Basri S.; Ng R.-X.; Ong H.-C.; Wong P.-L.; Syed Omar S.F.; Mahadeva S.
Published: (2024)

Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice
by: Ahmad Alwi N.A.; Lim S.M.; Mani V.; Ramasamy K.
Published: (2023)

The risk of prenatal bisphenol A exposure in early life neurodevelopment: Insights from epigenetic regulation
by: Nayan N.M.; Husin A.; Siran R.
Published: (2024)

The risk of prenatal bisphenol A exposure in early life neurodevelopment: Insights from epigenetic regulation
by: Nayan, et al.
Published: (2024)

Bibliometric analysis and review of research frontiers on Transient Receptor Potential Vanilloid 4 channels
by: Jamaludin S.Y.N.; Jahidin A.H.; Zakaria R.
Published: (2023)

Ripple suppression in 300GHz band cylindrical lens
by: Gray D.; Sakakibara K.; Suzuki S.; Ishihara R.; Sugimoto Y.; Kikuma N.; Yamada Y.; Abd Rahman N.H.
Published: (2021)

Transient natural convection in porous square cavity heated and cooled on adjacent walls
by: Selamat M.S.; Hashim I.; Hasan M.K.
Published: (2012)

SUPPRESSION OF SOMMERFELD EFFECT IN POWER TRANSMISSION SYSTEM EMPLOYING CARDAN SHAFT THROUGH PHASE ANGLE ARRANGEMENT
by: Omar M.H.; Rahim M.A.; Rejab M.N.A.M.; Rani M.N.A.
Published: (2024)

Tumor Suppressive Effects of GAS5 in Cancer Cells
by: Kaur J.; Salehen N.; Norazit A.; Rahman A.A.; Murad N.A.A.; Rahman N.M.A.N.A.; Ibrahim K.
Published: (2022)

Analysis of the influence of memory content of auditory stimuli on the memory content of EEG signal
by: Namazi H.; Khosrowabadi R.; Hussaini J.; Habibi S.; Farid A.A.; Kulish V.V.
Published: (2016)

Neurodevelopmental effects of prenatal Bisphenol A exposure on the role of microRNA regulating NMDA receptor subunits in the male rat hippocampus
by: Nayan N.M.; Kadir S.H.S.A.; Husin A.; Siran R.
Published: (2024)

Neurocognitive effects of Prunus domestica fruit extract on scopolamine-induced amnesic mice
by: Jayasingh Chellammal H.S.; Manan M.M.; Azil A.; Murugan Y.; Chelvam P.; Chandarasekaran P.
Published: (2020)

Liver dysfunction in adults with COVID-19 infection: A longitudinal study with transient elastography evaluation
by: Rajaram, et al.
Published: (2024)

Interference Suppression Performance of Automotive UWB Radars Using Pseudo Random Sequences
by: Pasya I.; Kato H.; Kobayashi T.
Published: (2015)

An evolutionary programming approach to optimize synchronous generator input power using area-based transient stability indexes
by: Hashim H.; Abidin I.Z.; Musirin I.; Siah Yap K.; Omar Y.R.; Zulkepali M.R.
Published: (2013)

Dynamic optimization of boiler for minimizing energy consumption in the intentionally transient process operation: Effect of different interval number
by: Rohman F.S.; Wan Alwi S.R.; Azmi A.; Er H.A.; Ahmad Termizi S.N.A.
Published: (2024)

Neurodevelopmental effects of prenatal Bisphenol A exposure on the role of microRNA regulating NMDA receptor subunits in the male rat hippocampus
by: Nayan, et al.
Published: (2024)

Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats
by: Agarwal R.; Gupta S.K.; Agarwal P.; Srivastava S.
Published: (2013)

Severe hyperthermia induces apoptosis mediated by caspases activation and suppression of Hsp90α expression in osteosarcoma cells
by: Nashiry M.A.; Froemming G.R.A.; Keong Y.S.; Ismail A.B.M.; Din A.M.; Al-Khateeb A.M.
Published: (2019)

Ticagrelor induces paraoxonase-1 (PON1) and better protects hypercholesterolemic mice against atherosclerosis compared to clopidogrel
by: Halim H.; Pinkaew D.; Chunhacha P.; Sinthujaroen P.; Thiagarajan P.; Fujise K.
Published: (2018)

Dynamic optimization of boiler for minimizing energy consumption in the intentionally transient process operation: effect of different interval number
by: Rohman, et al.
Published: (2024)

Osteoblast Demineralization Induced by Oxidized High-Density Lipoprotein via the Inflammatory Pathway Is Suppressed by Adiponectin
by: Harun N.H.; Froemming G.R.A.; Mohd Ismail A.; Nawawi H.; Mokhtar S.S.; Abd Muid S.
Published: (2022)

Management of Corporate Memory in the Organization
by: Azmi, et al.
Published: (2024)

Usability evaluation of personalized digital memory book for alzheimer’s patient (my-MOBAL)
by: Abu Hashim-de Vries A.H.; Ismail M.; Mohamed A.; Subramaniam P.
Published: (2020)

Vibration Suppression of the Flexible Beam Structure Using PID Controller Tuned by Advanced Firefly Algorithm
by: Ab Talib M.H.; Ismail M.I.S.; Mohd Yatim H.; Hadi M.S.; Mohd Saufi M.S.R.; Abdul Saad W.A.; Abu Hasan M.D.; Isham M.F.
Published: (2024)

Dietary menhaden fish oil supplementation suppresses lipopolysaccharide-induced neuroinflammation and cognitive impairment in diabetic rats
by: Titisari N.; Fauzi A.; Abdul Razak I.S.; Mohd Noor M.H.; Samsulrizal N.; Ahmad H.
Published: (2024)

Optimal design and transient simulation next to environmental consideration of net-zero energy buildings with green hydrogen production and energy storage system
by: Hai T.; Ashraf Ali M.; Dhahad H.A.; Alizadeh A.; Sharma A.; Fahad Almojil S.; Ibrahim Almohana A.; Fahmi Alali A.; Wang D.
Published: (2023)

Intelligent PID Controller Tuned by Bacterial Foraging Optimization Algorithm for Vibration Suppression of Horizontal Flexible Structure
by: Raof A.I.A.; Hadi M.S.; Jamali A.; Yatim H.M.; Talib M.H.A.; Darus I.Z.M.
Published: (2022)

Transient performance simulation and technoeconomic assessment of a smart building energy plant driven by solar energy coupled to a reversible heat pump
by: Hai T.; Liu Y.; Zhou J.; Li S.; Zain J.M.; Yusoff M.; Ben Moussa S.; Abd El-Gawad H.H.
Published: (2023)

A framework of MRI fat suppressed imaging fusion system for femur abnormality analysis
by: Meng B.C.C.; Ngah U.K.; Khoo B.E.; Shuaib I.L.; Aziz M.E.
Published: (2015)

Neuropharmacological studies of ethanolic extract of Vaccinium corymbosum on Alzheimer's type dementia and catatonia in Swiss albino mice
by: Chellammal H.S.J.; Menon B.V.V.; Hasan M.H.; Azil A.; Suhaimi M.T.B.; Chandarasekaran P.; Murugan Y.
Published: (2021)