Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening

Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene)) bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis- (methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were succes...

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Published in:Malaysian Journal of Fundamental and Applied Sciences
Main Author: Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K.
Format: Article
Language:English
Published: Penerbit UTM Press 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100687600&doi=10.11113%2fmjfas.v15n4.1508&partnerID=40&md5=575a78685d266e6bc3a7c5514ec5308e
id 2-s2.0-85100687600
spelling 2-s2.0-85100687600
Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K.
Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
2019
Malaysian Journal of Fundamental and Applied Sciences
15
4
10.11113/mjfas.v15n4.1508
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100687600&doi=10.11113%2fmjfas.v15n4.1508&partnerID=40&md5=575a78685d266e6bc3a7c5514ec5308e
Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene)) bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis- (methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were successfully synthesized, characterized and evaluated for their in vitro anticancer activities against human colon cancer cell lines, HCT116. The compounds were characterized using FT-IR, 1H and 13C NMR, UVVisible, elemental analysis and melting point. The anticancer results revealed that the parent ligands were more active than their corresponding complexes with L1F being the most potent anticancer compound with IC50 of 2.8 μg/ml. © 2019 Penerbit UTM Press. All rights reserved.
Penerbit UTM Press
2289599X
English
Article
All Open Access; Gold Open Access
author Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K.
spellingShingle Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K.
Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
author_facet Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K.
author_sort Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K.
title Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
title_short Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
title_full Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
title_fullStr Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
title_full_unstemmed Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
title_sort Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
publishDate 2019
container_title Malaysian Journal of Fundamental and Applied Sciences
container_volume 15
container_issue 4
doi_str_mv 10.11113/mjfas.v15n4.1508
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100687600&doi=10.11113%2fmjfas.v15n4.1508&partnerID=40&md5=575a78685d266e6bc3a7c5514ec5308e
description Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene)) bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis- (methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were successfully synthesized, characterized and evaluated for their in vitro anticancer activities against human colon cancer cell lines, HCT116. The compounds were characterized using FT-IR, 1H and 13C NMR, UVVisible, elemental analysis and melting point. The anticancer results revealed that the parent ligands were more active than their corresponding complexes with L1F being the most potent anticancer compound with IC50 of 2.8 μg/ml. © 2019 Penerbit UTM Press. All rights reserved.
publisher Penerbit UTM Press
issn 2289599X
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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