Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene)) bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis- (methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were succes...
Published in: | Malaysian Journal of Fundamental and Applied Sciences |
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Penerbit UTM Press
2019
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Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100687600&doi=10.11113%2fmjfas.v15n4.1508&partnerID=40&md5=575a78685d266e6bc3a7c5514ec5308e |
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2-s2.0-85100687600 Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K. Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening 2019 Malaysian Journal of Fundamental and Applied Sciences 15 4 10.11113/mjfas.v15n4.1508 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100687600&doi=10.11113%2fmjfas.v15n4.1508&partnerID=40&md5=575a78685d266e6bc3a7c5514ec5308e Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene)) bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis- (methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were successfully synthesized, characterized and evaluated for their in vitro anticancer activities against human colon cancer cell lines, HCT116. The compounds were characterized using FT-IR, 1H and 13C NMR, UVVisible, elemental analysis and melting point. The anticancer results revealed that the parent ligands were more active than their corresponding complexes with L1F being the most potent anticancer compound with IC50 of 2.8 μg/ml. © 2019 Penerbit UTM Press. All rights reserved. Penerbit UTM Press 2289599X English Article All Open Access; Gold Open Access |
author |
Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K. |
spellingShingle |
Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K. Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening |
author_facet |
Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K. |
author_sort |
Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K. |
title |
Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening |
title_short |
Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening |
title_full |
Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening |
title_fullStr |
Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening |
title_full_unstemmed |
Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening |
title_sort |
Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening |
publishDate |
2019 |
container_title |
Malaysian Journal of Fundamental and Applied Sciences |
container_volume |
15 |
container_issue |
4 |
doi_str_mv |
10.11113/mjfas.v15n4.1508 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100687600&doi=10.11113%2fmjfas.v15n4.1508&partnerID=40&md5=575a78685d266e6bc3a7c5514ec5308e |
description |
Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene)) bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis- (methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were successfully synthesized, characterized and evaluated for their in vitro anticancer activities against human colon cancer cell lines, HCT116. The compounds were characterized using FT-IR, 1H and 13C NMR, UVVisible, elemental analysis and melting point. The anticancer results revealed that the parent ligands were more active than their corresponding complexes with L1F being the most potent anticancer compound with IC50 of 2.8 μg/ml. © 2019 Penerbit UTM Press. All rights reserved. |
publisher |
Penerbit UTM Press |
issn |
2289599X |
language |
English |
format |
Article |
accesstype |
All Open Access; Gold Open Access |
record_format |
scopus |
collection |
Scopus |
_version_ |
1818940561495687168 |