Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene)) bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis- (methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were succes...
| Published in: | Malaysian Journal of Fundamental and Applied Sciences |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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Penerbit UTM Press
2019
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100687600&doi=10.11113%2fmjfas.v15n4.1508&partnerID=40&md5=575a78685d266e6bc3a7c5514ec5308e |
| Summary: | Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene)) bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis- (methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were successfully synthesized, characterized and evaluated for their in vitro anticancer activities against human colon cancer cell lines, HCT116. The compounds were characterized using FT-IR, 1H and 13C NMR, UVVisible, elemental analysis and melting point. The anticancer results revealed that the parent ligands were more active than their corresponding complexes with L1F being the most potent anticancer compound with IC50 of 2.8 μg/ml. © 2019 Penerbit UTM Press. All rights reserved. |
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| ISSN: | 2289599X |
| DOI: | 10.11113/mjfas.v15n4.1508 |