Biscoumarin analogs: Synthesis, α-glucosidase inhibitory potential and molecular docking study
Eighteen biscoumarin analogs (1-18) were synthesized in moderately good yields and characterized by various spectroscopic methods. The biscoumarin analogs were further evaluated for α-glucosidase inhibitory potential. Amongst this series of 18 analogs, 15 analogs showed outstanding α-glucosidase inh...
| Published in: | Malaysian Journal of Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Malaysian Institute of Chemistry
2020
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094925661&partnerID=40&md5=477a2fb23ddffc7683c81e172662e934 |
| Summary: | Eighteen biscoumarin analogs (1-18) were synthesized in moderately good yields and characterized by various spectroscopic methods. The biscoumarin analogs were further evaluated for α-glucosidase inhibitory potential. Amongst this series of 18 analogs, 15 analogs showed outstanding α-glucosidase inhibititory activity with IC50 values ranging from 14.39 ± 0.52 to 230.22 ± 0.83 μM when compared with the standard acarbose of IC50 value of 774.5 ± 1.94 μM, in which analog 4 was observed as the most active analog. Molecular docking study was carried out to understand the binding interaction of the compounds with the active site of α-glucosidase. Analog 4 was found to possess the most interaction with various proteins. This is in line with the findings in the α-glucosidase assay. © 2020 Malaysian Institute of Chemistry. All rights reserved. |
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| ISSN: | 15112292 |