Sperm DNA fragmentation: A new guideline for clinicians

Sperm DNA fragmentation: A new guideline for clinicians

Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abor...

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Bibliographic Details
Published in:World Journal of Men's Health
Main Author: Agarwal A.; Majzoub A.; Baskaran S.; Selvam M.K.P.; Cho C.L.; Henkel R.; Finelli R.; Leisegang K.; Sengupta P.; Barbarosie C.; Parekh N.; Alves M.G.; Ko E.; Arafa M.; Tadros N.; Ramasamy R.; Kavoussi P.; Ambar R.; Kuchakulla M.; Robert K.A.; Iovine C.; Durairajanayagam D.; Jindal S.; Shah R.
Format: Review
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2020
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093687092&doi=10.5534%2fWJMH.200128&partnerID=40&md5=08d6fa518a1ed12102f3c8a82deea806
Description
Summary:Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. In light of these clinical case reports and recent scientific evidence, this review provides expert recommendations on SDF testing and examines the advantages and drawbacks of the clinical utility of SDF testing using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis. Copyright © 2020 Korean Society for Sexual Medicine and Andrology
ISSN:22874208
DOI:10.5534/WJMH.200128

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