Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
Previous studies on Calophyllum species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinax...
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Taylor and Francis Ltd.
2021
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2-s2.0-85090459250 Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L. Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. 2021 Natural Product Research 35 24 10.1080/14786419.2020.1819273 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090459250&doi=10.1080%2f14786419.2020.1819273&partnerID=40&md5=150d705ad34ad3da8e43358dcdae6441 Previous studies on Calophyllum species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinaxanthone (3), thwaitesixanthone (4), caloxanthone B (5), trapezifolixanthone (6), β-mangostin (7), osajaxanthone (8), caloxanthone A (9), calozeyloxanthone (10) and rubraxanthone (11). The structures of these compounds were identified and elucidated using spectroscopic techniques such as NMR and MS. The cytotoxicity and nitric oxide production inhibitory activities of selected xanthones as well as the extracts were tested against HL-60 cells and RAW 264.7 murine macrophages, respectively. Among all tested compounds, β-mangostin exhibited appreciable cytotoxicity against HL-60 cells with the IC50 value of 7.16 ± 0.70 µg/mL and rubraxanthone exhibited significant nitric oxide inhibitory activity against LPS induced RAW 264.7 murine macrophages with the IC50 value of 6.45 ± 0.15 µg/mL. © 2020 Informa UK Limited, trading as Taylor & Francis Group. Taylor and Francis Ltd. 14786419 English Article |
author |
Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L. |
spellingShingle |
Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L. Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. |
author_facet |
Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L. |
author_sort |
Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L. |
title |
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. |
title_short |
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. |
title_full |
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. |
title_fullStr |
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. |
title_full_unstemmed |
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. |
title_sort |
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. |
publishDate |
2021 |
container_title |
Natural Product Research |
container_volume |
35 |
container_issue |
24 |
doi_str_mv |
10.1080/14786419.2020.1819273 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090459250&doi=10.1080%2f14786419.2020.1819273&partnerID=40&md5=150d705ad34ad3da8e43358dcdae6441 |
description |
Previous studies on Calophyllum species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinaxanthone (3), thwaitesixanthone (4), caloxanthone B (5), trapezifolixanthone (6), β-mangostin (7), osajaxanthone (8), caloxanthone A (9), calozeyloxanthone (10) and rubraxanthone (11). The structures of these compounds were identified and elucidated using spectroscopic techniques such as NMR and MS. The cytotoxicity and nitric oxide production inhibitory activities of selected xanthones as well as the extracts were tested against HL-60 cells and RAW 264.7 murine macrophages, respectively. Among all tested compounds, β-mangostin exhibited appreciable cytotoxicity against HL-60 cells with the IC50 value of 7.16 ± 0.70 µg/mL and rubraxanthone exhibited significant nitric oxide inhibitory activity against LPS induced RAW 264.7 murine macrophages with the IC50 value of 6.45 ± 0.15 µg/mL. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
publisher |
Taylor and Francis Ltd. |
issn |
14786419 |
language |
English |
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Article |
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record_format |
scopus |
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Scopus |
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1809678159173386240 |