Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.

Previous studies on Calophyllum species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinax...

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Published in:Natural Product Research
Main Author: Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L.
Format: Article
Language:English
Published: Taylor and Francis Ltd. 2021
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090459250&doi=10.1080%2f14786419.2020.1819273&partnerID=40&md5=150d705ad34ad3da8e43358dcdae6441
id 2-s2.0-85090459250
spelling 2-s2.0-85090459250
Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L.
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
2021
Natural Product Research
35
24
10.1080/14786419.2020.1819273
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090459250&doi=10.1080%2f14786419.2020.1819273&partnerID=40&md5=150d705ad34ad3da8e43358dcdae6441
Previous studies on Calophyllum species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinaxanthone (3), thwaitesixanthone (4), caloxanthone B (5), trapezifolixanthone (6), β-mangostin (7), osajaxanthone (8), caloxanthone A (9), calozeyloxanthone (10) and rubraxanthone (11). The structures of these compounds were identified and elucidated using spectroscopic techniques such as NMR and MS. The cytotoxicity and nitric oxide production inhibitory activities of selected xanthones as well as the extracts were tested against HL-60 cells and RAW 264.7 murine macrophages, respectively. Among all tested compounds, β-mangostin exhibited appreciable cytotoxicity against HL-60 cells with the IC50 value of 7.16 ± 0.70 µg/mL and rubraxanthone exhibited significant nitric oxide inhibitory activity against LPS induced RAW 264.7 murine macrophages with the IC50 value of 6.45 ± 0.15 µg/mL. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Taylor and Francis Ltd.
14786419
English
Article

author Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L.
spellingShingle Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L.
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
author_facet Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L.
author_sort Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L.
title Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
title_short Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
title_full Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
title_fullStr Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
title_full_unstemmed Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
title_sort Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
publishDate 2021
container_title Natural Product Research
container_volume 35
container_issue 24
doi_str_mv 10.1080/14786419.2020.1819273
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090459250&doi=10.1080%2f14786419.2020.1819273&partnerID=40&md5=150d705ad34ad3da8e43358dcdae6441
description Previous studies on Calophyllum species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinaxanthone (3), thwaitesixanthone (4), caloxanthone B (5), trapezifolixanthone (6), β-mangostin (7), osajaxanthone (8), caloxanthone A (9), calozeyloxanthone (10) and rubraxanthone (11). The structures of these compounds were identified and elucidated using spectroscopic techniques such as NMR and MS. The cytotoxicity and nitric oxide production inhibitory activities of selected xanthones as well as the extracts were tested against HL-60 cells and RAW 264.7 murine macrophages, respectively. Among all tested compounds, β-mangostin exhibited appreciable cytotoxicity against HL-60 cells with the IC50 value of 7.16 ± 0.70 µg/mL and rubraxanthone exhibited significant nitric oxide inhibitory activity against LPS induced RAW 264.7 murine macrophages with the IC50 value of 6.45 ± 0.15 µg/mL. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
publisher Taylor and Francis Ltd.
issn 14786419
language English
format Article
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