Synthesis of some N-sulfonated derivatives of 1-[(E)-3-phenyl-2-propenyl]piperazine as suitable antibacterial agents

• Published in: Pakistan Journal of Pharmaceutical Sciences
• Main Author: Abbasi M.A.; Ijaz M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Fatima H.
• Format: Article
• Language: English
• Published: Pakistan Journal of Pharmaceutical Sciences 2020
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090169024&doi=10.36721%2fPJPS.2020.33.4.REG.1609-1616.1&partnerID=40&md5=c5ad2c322e8352368be2adef1861abc6

In the planned research work, the nucleophilic substitution reaction of 1-[(E)-3-phenyl-2-propenyl]piperazine (1) was carried out with different sulfonyl chlorides (2a-g) at pH 9-10 to synthesize its different N-sulfonated derivatives (3a-g). The structures of the synthesized compounds were characterized by their proton-nuclear magnetic resonance (1H-NMR), carbon-nuclear magnetic resonance (13C-NMR) and Infra Red (IR) spectral data, along with CHN analysis. The inhibition potential of the synthesized molecules was ascertained against two bacterial pathogenic strains i.e. Bacillus subtilis and Escherichia coli. It was inferred from the results that some of the compounds were very suitable inhibitors of these bacterial strains. Moreover, their cytotoxicity was also profiled and it was outcome that most of these molecules possessed moderate cytotoxicity. © 2020 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.