Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies

Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies

A series of 2,3-diaryldibenzo[b]thiophene derivatives have been synthesized via Suzuki coupling reactions in moderate to good yields (59–79%). The synthesized compounds were evaluated for their antithrombolytic, biofilm inhibition, and hemolytic potential. All compounds showed significant biological...

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Published in:Medicinal Chemistry Research
Main Author: Sial N.; Rasool N.; Rizwan K.; Altaf A.A.; Ali S.; Malik A.; Zubair M.; Akhtar A.; Kausar S.; Shah S.A.A.
Format: Article
Language:English
Published: Springer 2020
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085920123&doi=10.1007%2fs00044-020-02568-7&partnerID=40&md5=0a79dc181244a474afa6f789c1afeba2
id 2-s2.0-85085920123
spelling 2-s2.0-85085920123
Sial N.; Rasool N.; Rizwan K.; Altaf A.A.; Ali S.; Malik A.; Zubair M.; Akhtar A.; Kausar S.; Shah S.A.A.
Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
2020
Medicinal Chemistry Research
29
8
10.1007/s00044-020-02568-7
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085920123&doi=10.1007%2fs00044-020-02568-7&partnerID=40&md5=0a79dc181244a474afa6f789c1afeba2
A series of 2,3-diaryldibenzo[b]thiophene derivatives have been synthesized via Suzuki coupling reactions in moderate to good yields (59–79%). The synthesized compounds were evaluated for their antithrombolytic, biofilm inhibition, and hemolytic potential. All compounds showed significant biological potential. Compound (4k) revealed excellent antithrombolytic (87.24%) and biofilm inhibition (99.64%) activity. While compound (4i) exhibited an outstanding hemolytic potential (84.53%). The docking studies uncovered that studied compounds interact with streptokinase and plasminogen via hydrogen bonding, π-anion, π–π stacked interactions, and π-sigma bonding type interactions. The results revealed that synthesized benzo[b]thiophene derivatives could be a potential source of therapeutic agents. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Springer
10542523
English
Article
author Sial N.; Rasool N.; Rizwan K.; Altaf A.A.; Ali S.; Malik A.; Zubair M.; Akhtar A.; Kausar S.; Shah S.A.A.
spellingShingle Sial N.; Rasool N.; Rizwan K.; Altaf A.A.; Ali S.; Malik A.; Zubair M.; Akhtar A.; Kausar S.; Shah S.A.A.
Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
author_facet Sial N.; Rasool N.; Rizwan K.; Altaf A.A.; Ali S.; Malik A.; Zubair M.; Akhtar A.; Kausar S.; Shah S.A.A.
author_sort Sial N.; Rasool N.; Rizwan K.; Altaf A.A.; Ali S.; Malik A.; Zubair M.; Akhtar A.; Kausar S.; Shah S.A.A.
title Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
title_short Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
title_full Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
title_fullStr Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
title_full_unstemmed Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
title_sort Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
publishDate 2020
container_title Medicinal Chemistry Research
container_volume 29
container_issue 8
doi_str_mv 10.1007/s00044-020-02568-7
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085920123&doi=10.1007%2fs00044-020-02568-7&partnerID=40&md5=0a79dc181244a474afa6f789c1afeba2
description A series of 2,3-diaryldibenzo[b]thiophene derivatives have been synthesized via Suzuki coupling reactions in moderate to good yields (59–79%). The synthesized compounds were evaluated for their antithrombolytic, biofilm inhibition, and hemolytic potential. All compounds showed significant biological potential. Compound (4k) revealed excellent antithrombolytic (87.24%) and biofilm inhibition (99.64%) activity. While compound (4i) exhibited an outstanding hemolytic potential (84.53%). The docking studies uncovered that studied compounds interact with streptokinase and plasminogen via hydrogen bonding, π-anion, π–π stacked interactions, and π-sigma bonding type interactions. The results revealed that synthesized benzo[b]thiophene derivatives could be a potential source of therapeutic agents. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
publisher Springer
issn 10542523
language English
format Article
accesstype
record_format scopus
collection Scopus
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