Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecular docking studies
A series of 2,3-diaryldibenzo[b]thiophene derivatives have been synthesized via Suzuki coupling reactions in moderate to good yields (59–79%). The synthesized compounds were evaluated for their antithrombolytic, biofilm inhibition, and hemolytic potential. All compounds showed significant biological...
| Published in: | Medicinal Chemistry Research |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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Springer
2020
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085920123&doi=10.1007%2fs00044-020-02568-7&partnerID=40&md5=0a79dc181244a474afa6f789c1afeba2 |
| Summary: | A series of 2,3-diaryldibenzo[b]thiophene derivatives have been synthesized via Suzuki coupling reactions in moderate to good yields (59–79%). The synthesized compounds were evaluated for their antithrombolytic, biofilm inhibition, and hemolytic potential. All compounds showed significant biological potential. Compound (4k) revealed excellent antithrombolytic (87.24%) and biofilm inhibition (99.64%) activity. While compound (4i) exhibited an outstanding hemolytic potential (84.53%). The docking studies uncovered that studied compounds interact with streptokinase and plasminogen via hydrogen bonding, π-anion, π–π stacked interactions, and π-sigma bonding type interactions. The results revealed that synthesized benzo[b]thiophene derivatives could be a potential source of therapeutic agents. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. |
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| ISSN: | 10542523 |
| DOI: | 10.1007/s00044-020-02568-7 |