Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]

Hydroxamic acids, RCONHOH, are electronically flexible compounds for organic and inorganic analyses due to their more delicate structures compared to carboxylic acid. These acids are easy to deprotonate to produce hydroxamate ions. The syntheses, physico-chemical and characterization of benzohydroxa...

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Published in:Malaysian Journal of Analytical Sciences
Main Author: Latifah Robbaniyyah H.; Bahron H.; Ramasamy K.; Tajuddin A.M.
Format: Article
Language:English
Published: Malaysian Society of Analytical Sciences 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085547339&doi=10.17576%2fmjas-2019-2302-11&partnerID=40&md5=d707c7f6beeab204985d59bee9f6c62c
id 2-s2.0-85085547339
spelling 2-s2.0-85085547339
Latifah Robbaniyyah H.; Bahron H.; Ramasamy K.; Tajuddin A.M.
Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]
2019
Malaysian Journal of Analytical Sciences
23
2
10.17576/mjas-2019-2302-11
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085547339&doi=10.17576%2fmjas-2019-2302-11&partnerID=40&md5=d707c7f6beeab204985d59bee9f6c62c
Hydroxamic acids, RCONHOH, are electronically flexible compounds for organic and inorganic analyses due to their more delicate structures compared to carboxylic acid. These acids are easy to deprotonate to produce hydroxamate ions. The syntheses, physico-chemical and characterization of benzohydroxamic acid (BHA) and methylbenzohydroxamic acid (CH3-BHA) and their metal complexes VO(IV), Cr(III) and Ni(II) are reported herein. The metal complexes were synthesized by condensation reaction of BHA and CH3-BHA with metal salts in 2:1 molar ratio. The compounds were characterized by elemental analysis, infrared spectroscopy (IR), 1H and 13C NMR, UV-Vis, TGA, magnetic susceptibility and molar conductance. From IR and magnetic susceptibility data, each complex is coordinated to the metal via oxygen and oxygen (O,O) in bidentate manner. The geometry of all metal complexes is octahedral except for [VO(BHA)2] that is square-pyramidal. The molar conductance values suggested that all complexes are non-electrolytic. A cytotoxicity study against human colorectal cancer, HCT116 cell lines, revealed that all the complexes are better anticancer agents than their parent ligands. © 2019, Malaysian Society of Analytical Sciences. All rights reserved.
Malaysian Society of Analytical Sciences
13942506
English
Article
All Open Access; Gold Open Access
author Latifah Robbaniyyah H.; Bahron H.; Ramasamy K.; Tajuddin A.M.
spellingShingle Latifah Robbaniyyah H.; Bahron H.; Ramasamy K.; Tajuddin A.M.
Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]
author_facet Latifah Robbaniyyah H.; Bahron H.; Ramasamy K.; Tajuddin A.M.
author_sort Latifah Robbaniyyah H.; Bahron H.; Ramasamy K.; Tajuddin A.M.
title Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]
title_short Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]
title_full Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]
title_fullStr Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]
title_full_unstemmed Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]
title_sort Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]
publishDate 2019
container_title Malaysian Journal of Analytical Sciences
container_volume 23
container_issue 2
doi_str_mv 10.17576/mjas-2019-2302-11
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085547339&doi=10.17576%2fmjas-2019-2302-11&partnerID=40&md5=d707c7f6beeab204985d59bee9f6c62c
description Hydroxamic acids, RCONHOH, are electronically flexible compounds for organic and inorganic analyses due to their more delicate structures compared to carboxylic acid. These acids are easy to deprotonate to produce hydroxamate ions. The syntheses, physico-chemical and characterization of benzohydroxamic acid (BHA) and methylbenzohydroxamic acid (CH3-BHA) and their metal complexes VO(IV), Cr(III) and Ni(II) are reported herein. The metal complexes were synthesized by condensation reaction of BHA and CH3-BHA with metal salts in 2:1 molar ratio. The compounds were characterized by elemental analysis, infrared spectroscopy (IR), 1H and 13C NMR, UV-Vis, TGA, magnetic susceptibility and molar conductance. From IR and magnetic susceptibility data, each complex is coordinated to the metal via oxygen and oxygen (O,O) in bidentate manner. The geometry of all metal complexes is octahedral except for [VO(BHA)2] that is square-pyramidal. The molar conductance values suggested that all complexes are non-electrolytic. A cytotoxicity study against human colorectal cancer, HCT116 cell lines, revealed that all the complexes are better anticancer agents than their parent ligands. © 2019, Malaysian Society of Analytical Sciences. All rights reserved.
publisher Malaysian Society of Analytical Sciences
issn 13942506
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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