Synthesis and characterization of benzohydroxamic acid and methylbenzohydroxamic acid metal complexes and their cytotoxicty study; [Sintesis dan pencirian kompleks logam asid benzohidroksamik dan asid metilbenzohidroksamik serta kajian sitotoksik]

• Published in: Malaysian Journal of Analytical Sciences
• Main Author: Latifah Robbaniyyah H.; Bahron H.; Ramasamy K.; Tajuddin A.M.
• Format: Article
• Language: English
• Published: Malaysian Society of Analytical Sciences 2019
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085547339&doi=10.17576%2fmjas-2019-2302-11&partnerID=40&md5=d707c7f6beeab204985d59bee9f6c62c

Hydroxamic acids, RCONHOH, are electronically flexible compounds for organic and inorganic analyses due to their more delicate structures compared to carboxylic acid. These acids are easy to deprotonate to produce hydroxamate ions. The syntheses, physico-chemical and characterization of benzohydroxamic acid (BHA) and methylbenzohydroxamic acid (CH3-BHA) and their metal complexes VO(IV), Cr(III) and Ni(II) are reported herein. The metal complexes were synthesized by condensation reaction of BHA and CH3-BHA with metal salts in 2:1 molar ratio. The compounds were characterized by elemental analysis, infrared spectroscopy (IR), 1H and 13C NMR, UV-Vis, TGA, magnetic susceptibility and molar conductance. From IR and magnetic susceptibility data, each complex is coordinated to the metal via oxygen and oxygen (O,O) in bidentate manner. The geometry of all metal complexes is octahedral except for [VO(BHA)2] that is square-pyramidal. The molar conductance values suggested that all complexes are non-electrolytic. A cytotoxicity study against human colorectal cancer, HCT116 cell lines, revealed that all the complexes are better anticancer agents than their parent ligands. © 2019, Malaysian Society of Analytical Sciences. All rights reserved.