Synthesis, β-glucuronidase inhibition and molecular docking studies of cyano-substituted bisindole hydrazone hybrids

Abstract: The β-glucuronidase, a lysosomal enzyme, catalyzes the cleavage of glucuronosyl-O-bonds. Its inhibitors play a significant role in different medicinal therapies as they cause a decrease in carcinogen-induced colonic tumors by reducing the level of toxic substances present in the intestine....

詳細記述

書誌詳細
出版年:Molecular Diversity
第一著者: Abid O.; Imran S.; Taha M.; Ismail N.H.; Jamil W.; Kashif S.M.; Khan K.M.; Yusoff J.
フォーマット: 論文
言語:English
出版事項: Springer Science and Business Media Deutschland GmbH 2021
オンライン・アクセス:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083494465&doi=10.1007%2fs11030-020-10084-4&partnerID=40&md5=1a1f9de60075778928939203e78caf38