Virtual screening, ADME study, and molecular dynamic simulation of chalcone and flavone derivatives as 5-Lipoxygenase (5-LO) inhibitor

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Virtual screening, ADME study, and molecular dynamic simulation of chalcone and flavone derivatives as 5-Lipoxygenase (5-LO) inhibitor

5-Lipoxygenase (5-LO) is one of the key enzymes involved in the production of pro-inflammatory mediators, such as leukotriene B4 and cysteinyl leukotrienes. Inhibition of 5-LO is a promising therapeutic strategy against inflammation. Chalcones and flavones are known to have a broad spectrum of biolo...

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Bibliographic Details
Published in:	Molecular Simulation
Main Author:	Mohd Amin S.N.; Md Idris M.H.; Selvaraj M.; Mohd Amin S.N.; Jamari H.; Kek T.L.; Salleh M.Z.
Format:	Article
Language:	English
Published:	Taylor and Francis Ltd. 2020
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081355590&doi=10.1080%2f08927022.2020.1732961&partnerID=40&md5=97bf92718564f71310f070f465f5383e

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