Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
In the current research work, different N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides have been synthesized according to the protocol described in scheme 1. The synthesis was initiated by reacting various substituted anilines (1a-e) with 4-chlorobutanoyl chloride (...
Published in: | Bioorganic Chemistry |
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Main Author: | Raza H.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Abbas Q.; Hong H.; Shah S.A.A.; Shahid M.; Seo S.-Y. |
Format: | Article |
Language: | English |
Published: |
Academic Press Inc.
2020
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Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076239103&doi=10.1016%2fj.bioorg.2019.103445&partnerID=40&md5=24bac606e09b402de93524e55f2ab786 |
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