Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches

The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a...

Full description

Bibliographic Details
Published in:Journal of Natural Products
Main Author: Salim F.; Yunus Y.M.; Anouar E.H.; Awang K.; Langat M.; Cordell G.A.; Ahmad R.
Format: Article
Language:English
Published: American Chemical Society 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074696710&doi=10.1021%2facs.jnatprod.8b00380&partnerID=40&md5=37150565f25e064d7ada8647acbb9d8c
Description
Summary:The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a combination of physical data interpretation and quantum chemical calculations using the time-dependent density functional theory (TDDFT) method. Copyright © 2019 American Chemical Society and American Society of Pharmacognosy.
ISSN:1633864
DOI:10.1021/acs.jnatprod.8b00380