Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis

Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis

Flaviviruses are group of single stranded RNA viruses that cause severe endemic infection and epidemics on a global scale. It presents a significant health impact worldwide and the viruses have the potential to emerge and outbreak in a non-endemic geographical region. Effective vaccines for prophyla...

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Bibliographic Details
Published in:Virus Research
Main Author: Chong H.Y.; Leow C.Y.; Abdul Majeed A.B.; Leow C.H.
Format: Review
Language:English
Published: Elsevier B.V. 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073441660&doi=10.1016%2fj.virusres.2019.197770&partnerID=40&md5=ffd66a412a11a6449158d5ce115d892e
id 2-s2.0-85073441660
spelling 2-s2.0-85073441660
Chong H.Y.; Leow C.Y.; Abdul Majeed A.B.; Leow C.H.
Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis
2019
Virus Research
274

10.1016/j.virusres.2019.197770
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073441660&doi=10.1016%2fj.virusres.2019.197770&partnerID=40&md5=ffd66a412a11a6449158d5ce115d892e
Flaviviruses are group of single stranded RNA viruses that cause severe endemic infection and epidemics on a global scale. It presents a significant health impact worldwide and the viruses have the potential to emerge and outbreak in a non-endemic geographical region. Effective vaccines for prophylaxis are only available for several flaviviruses such as Yellow Fever virus, Tick-borne Encephalitis Virus, Dengue Virus and Japanese Encephalitis Virus and there is no antiflaviviral agent being marketed. This review discusses the flavivirus genome, replication cycle, epidemiology, clinical presentation and pathogenesis upon infection. Effective humoral response is critical to confer protective immunity against flaviviruses. Hence, we have also highlighted the immune responses elicited upon infection, various diagnostic facilities available for flaviviral disease and monoclonal antibodies available to date against flavivirus infection. © 2019 Elsevier B.V.
Elsevier B.V.
01681702
English
Review
author Chong H.Y.; Leow C.Y.; Abdul Majeed A.B.; Leow C.H.
spellingShingle Chong H.Y.; Leow C.Y.; Abdul Majeed A.B.; Leow C.H.
Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis
author_facet Chong H.Y.; Leow C.Y.; Abdul Majeed A.B.; Leow C.H.
author_sort Chong H.Y.; Leow C.Y.; Abdul Majeed A.B.; Leow C.H.
title Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis
title_short Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis
title_full Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis
title_fullStr Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis
title_full_unstemmed Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis
title_sort Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis
publishDate 2019
container_title Virus Research
container_volume 274
container_issue
doi_str_mv 10.1016/j.virusres.2019.197770
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073441660&doi=10.1016%2fj.virusres.2019.197770&partnerID=40&md5=ffd66a412a11a6449158d5ce115d892e
description Flaviviruses are group of single stranded RNA viruses that cause severe endemic infection and epidemics on a global scale. It presents a significant health impact worldwide and the viruses have the potential to emerge and outbreak in a non-endemic geographical region. Effective vaccines for prophylaxis are only available for several flaviviruses such as Yellow Fever virus, Tick-borne Encephalitis Virus, Dengue Virus and Japanese Encephalitis Virus and there is no antiflaviviral agent being marketed. This review discusses the flavivirus genome, replication cycle, epidemiology, clinical presentation and pathogenesis upon infection. Effective humoral response is critical to confer protective immunity against flaviviruses. Hence, we have also highlighted the immune responses elicited upon infection, various diagnostic facilities available for flaviviral disease and monoclonal antibodies available to date against flavivirus infection. © 2019 Elsevier B.V.
publisher Elsevier B.V.
issn 01681702
language English
format Review
accesstype
record_format scopus
collection Scopus
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