2-mercaptobenzimidazole schiff bases: Design, synthesis, antimicrobial studies and anticancer activity on HCT-116 cell line

QR Code

2-mercaptobenzimidazole schiff bases: Design, synthesis, antimicrobial studies and anticancer activity on HCT-116 cell line

Background: Increased rate of mortality due to the development of resistance to currently available antimicrobial and anticancer agents initiated the need to develop new chemical entities for the treatment of microbial infections and cancer. Objective: The present study was aimed to synthesize and e...

Full description

Bibliographic Details
Published in:	Mini-Reviews in Medicinal Chemistry
Main Author:	Tahlan S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Format:	Article
Language:	English
Published:	Bentham Science Publishers 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071752332&doi=10.2174%2f1389557518666181009151008&partnerID=40&md5=33a05942a654f4141b0ff0fa25ac4f8b

Similar Items

Diazenyl schiff bases: Synthesis, spectral analysis, antimicrobial studies and cytotoxic activity on human colorectal carcinoma cell line (HCT-116)
by: Kaur H.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Narasimhan B.
Published: (2020)

Design, synthesis, sar study, antimicrobial and anticancer evaluation of novel 2-mercaptobenzimidazole azomethine derivatives
by: Tahlan S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2020)

Gelam (Melaleuca sp.) honey demonstrates antiproliferative effect on colon cancer cell lines (HCT116)
by: Fadhli M.R.M.N.; Noorfathiah I.; Hana M.A.N.F.; Ashraf M.S.M.; Zolkapli E.; Mizaton H.H.; Iryani W.I.W.
Published: (2012)

In-silico molecular design of heterocyclic benzimidazole scaffolds as prospective anticancer agents
by: Tahlan S.; Kumar S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2019)

Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents
by: Kakkar S.; Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2018)

Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4′-(1,4-phenylene) bis(pyrimidin-2-amine) derivatives
by: Kumar S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Published: (2018)

Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents
by: Tahlan S.; Kumar S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Pathania R.; Narasimhan B.
Published: (2019)

4-Thiazolidinone derivatives: Synthesis, antimicrobial, anticancer evaluation and QSAR studies
by: Deep A.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mishra R.K.; Mani V.
Published: (2016)

Design, synthesis and biological potential of 5-(2-amino-6-(3/4-bromophenyl)pyrimidin-4-yl)benzene-1,3-diol scaffolds as promising antimicrobial and anticancer agents
by: Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Ali Shah S.A.
Published: (2019)

Benzoxazole derivatives: design, synthesis and biological evaluation
by: Kakkar S.; Tahlan S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Published: (2018)

4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2019)

Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2018)

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides
by: Yadav S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Mathur A.; Narasimhan B.
Published: (2018)

Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
by: Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
Published: (2014)

N′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: Synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies
by: Kumar P.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; De Clercq E.
Published: (2013)

Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents
by: Kumar S.; Kaushik A.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2019)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
by: Kumari M.; Tahlan S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Kakkar S.
Published: (2021)

Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents
by: Sharma D.; Kumar S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.
Published: (2019)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Clercq E.D.; Narasimhan B.
Published: (2014)

4-(1-Aryl-5-chloro-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides: Synthesis, antimicrobial, anticancer evaluation and QSAR studies
by: Kumar M.; Narasimhan B.; Kumar P.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2014)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
by: Kumar S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Selvaraj M.; Narasimhan B.
Published: (2017)

Design, synthesis and therapeutic potential of some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues
by: Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2019)

Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
by: Kakkar S.; Kumar S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Published: (2018)

Anti-cancer potential of benzophenone-bis-Schiff bases on human pancreatic cancer cell line
by: Khan K.M.; Rasheed H.; Fatima B.; Hayat M.; Rahim F.; Ullah H.; Hameed A.; Taha M.; Tahir A.; Perveen S.
Published: (2016)

Bis-pyrimidine acetamides: Design, synthesis and biological evaluation
by: Kumar S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Narasimhan B.
Published: (2017)

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives
by: Kumar S.; Singh J.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2018)

4-(4-Bromophenyl)-Thiazol-2-Amine derivatives: Synthesis, biological activity and molecular docking study with ADME profile
by: Sharma D.; Kumar S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.
Published: (2019)

Computational approaches: Discovery of GTPase HRas as prospective drug target for 1,3-diazine scaffolds
by: Kumar S.; Sharma D.; Narasimhan B.; Ramasamy K.; Shah S.A.A.; Lim S.M.; Mani V.
Published: (2019)

Synthesis, antimicrobial and cytotoxic evaluation of 4-(1-aryl-5-halo-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2017)

Synthesis and biological profile of substituted benzimidazoles
by: Vashist N.; Sambi S.S.; Narasimhan B.; Kumar S.; Lim S.M.; Shah S.A.A.; Ramasamy K.; Mani V.
Published: (2018)

Synthesis, characterization and anticancer activity of mono- and dinuclear Ni(II) and Co(II) complexes of a Schiff base derived from o-vanillin
by: Bahron H.; Khaidir S.S.; Tajuddin A.M.; Ramasamy K.; Yamin B.M.
Published: (2019)

Zinc(II)-Schiff base complex functionalized on gold nanospheres: synthesis, characterization, anticancer study and interaction with proteins
by: Ng Y.Z.; Tan K.W.; Chung L.Y.; Salim F.; Low M.L.; Ooi I.H.; Yip F.W.; Ng C.H.
Published: (2022)

Cytotoxicity of anchusa arvensis against HepG-2 cell lines: Mechanistic and computational approaches
by: Hussain S.; Ullah F.; Sadiq A.; Ayaz M.; Shah A.-U.-H.A.; Shah S.A.A.; Shah S.M.; Nadhman A.; Ullah F.; Wadood A.; El-Shazly M.
Published: (2019)

Synthesis, anticancer, molecular docking and QSAR studies of benzoylhydrazone
by: Taha M.; Sultan S.; Herizal M.; Fatmi M.Q.; Selvaraj M.; Ramasamy K.; Halim S.A.; Lim S.M.; Rahim F.; Ashraf K.; Shehzad A.
Published: (2019)

Cell membrane cloaked nanomedicines for bio-imaging and immunotherapy of cancer: Improved pharmacokinetics, cell internalization and anticancer efficacy
by: Hussain Z.; Rahim M.A.; Jan N.; Shah H.; Rawas-Qalaji M.; Khan S.; Sohail M.; Thu H.E.; Ramli N.A.; Sarfraz R.M.; Abourehab M.A.S.
Published: (2021)

Synthesis, Spectral Characterization, Catalytic and Antimicrobial Activities of Pd(II) and Ni(II) Schiff Base Complexes
by: Ahmad S.N.; Parumasivam T.; Nasaruddin N.H.; Khaidir S.S.
Published: (2024)

Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides
by: Yadav S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Selvaraj M.
Published: (2017)

Goniothalamus umbrosus Induces Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell Line
by: Aziz N.C.; Alahmad B.E.M.; Kashmoola M.A.; Lestari W.; Mokhtar K.I.; Rosdy N.M.M.N.M.
Published: (2024)

Antiproliferative properties of clausine-B against cancer cell lines
by: Wan Mohd Zain W.N.I.; Rahmat A.; Othman F.; Yap T.Y.H.
Published: (2009)

Anticancer molecules from catharanthus roseus
by: Taher Z.M.; Agouillal F.; Lim J.R.; Marof A.Q.; Dailin D.J.; Nurjayadi M.; Razif E.N.M.; Gomaa S.E.; El Enshasy H.A.
Published: (2019)