Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer's Disease Mouse Model

QR Code

Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer's Disease Mouse Model

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and other cognitive abilities. AD is associated with aggregation of amyloid-β (Aβ) deposited in the hippocampal brain region. Our previous work has shown that tocotrienol rich fraction (TRF) sup...

Full description

Bibliographic Details
Published in:	Journal of Alzheimer's Disease
Main Author:	Nasri W.N.W.; Makpol S.; Mazlan M.; Tooyama I.; Ngah W.Z.W.; Damanhuri H.A.
Format:	Article
Language:	English
Published:	IOS Press 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071288588&doi=10.3233%2fJAD-180496&partnerID=40&md5=5aa2c60f62faff9d5dfd7eda8b1dee39

Similar Items

Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats
by: Mazlan M.; Hamezah H.S.; Taridi N.M.; Jing Y.; Liu P.; Zhang H.; Wan Ngah W.Z.; Damanhuri H.A.
Published: (2017)

Palm tocotrienol-rich fraction supplementation suppressed stress-induced gastric oxidative stress in rats
by: Kamisah Y.; Ibrahim A.A.I.; Nafeeza M.I.; Nur-Azlina M.F.
Published: (2011)

Effect of coenzyme Q10 supplementation on post-vitrification mouse embryo development
by: Anisa-Annur S.; Wan-Hafizah W.J.; Nor-Ashikin M.N.K.; Muhammad-Zaki R.
Published: (2024)

Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake
by: Ramli N.Z.; Yahaya M.F.; Fahami N.A.M.; Hamezah H.S.; Bakar Z.H.A.; Arrozi A.P.; Yanagisawa D.; Tooyama I.; Singh M.; Damanhuri H.A.
Published: (2024)

Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake
by: Ramli, et al.
Published: (2024)

Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats
by: Taridi N.M.; Abd Rani N.; Abd Latiff A.; Wan Ngah W.Z.; Mazlan M.
Published: (2014)

Tocotrienol-rich fraction supplementation prevents foetal loss in females mated with corticosterone-treated male Sprague–Dawley rats
by: Abd Aziz N.A.A.; Chatterjee A.; Chatterjee R.; Durairajanayagam D.
Published: (2019)

Behavioral assessment and blood oxidative status of aging sprague dawley rats through a longitudinal analysis
by: Achin N.A.; Kit T.J.; Ngah W.Z.W.; Makpol S.; Mazlan M.; Hamezah H.S.; Damanhuri H.A.
Published: (2018)

Dose dependent elevation of plasma tocotrienol levels and its effect on arterial compliance, plasma total antioxidant status, and lipid profile in healthy humans supplemented with tocotrienol rich vitamin E
by: Rasool A.H.G.; Yuen K.H.; Yusoff K.; Wong A.R.; Rahman A.R.A.
Published: (2006)

Palm tocotrienol rich fraction with palm kernel oil supplementation prevents development of liver steatosis in high fat diet ICR mice
by: Goon M.D.M.E.; Zulkanain N.I.; Kadir S.H.S.A.; Rahim S.A.; Mazlan M.; Latip N.A.; Aziz M.A.; Noor N.M.
Published: (2022)

Untargeted serum metabolites profiling in high-fat diet mice supplemented with enhanced palm tocotrienol-rich fraction using UHPLC-MS
by: Goon D.E.; Ab-Rahim S.; Mohd Sakri A.H.; Mazlan M.; Tan J.K.; Abdul Aziz M.; Mohd Noor N.; Ibrahim E.; Sheikh Abdul Kadir S.H.
Published: (2021)

Palm-based tocotrienol-rich fraction (TRF) supplementation modulates cardiac sod1 expression, fxr target gene expression, and tauro-conjugated bile acid levels in aleptinemic mice fed a high-fat diet
by: Md Shahrulnizam N.A.N.; Mohd Efendy Goon M.D.; Ab Rahim S.; Lew S.W.; Sheikh Abdul Kadir S.H.; Ibrahim E.
Published: (2024)

Analysis of expression of vitamin E-binding proteins in H2O2induced SK-N-SH neuronal cells supplemented with α-tocopherol and tocotrienol-rich fraction
by: Chiroma A.A.; Khaza'ai H.; Hamid R.A.; Chang S.K.; Zakaria Z.A.; Zainal Z.
Published: (2020)

Protective effects of virgin coconut oil and tocotrienol-rich fraction on bone biomechanics
by: Malik M.M.A.; Ghani D.F.C.A.; Uzaimi A.N.; Shuid A.N.
Published: (2020)

Palm Tocotrienol-Rich Fraction Improves the Quality and Development of Embryos in Streptozotocin-Induced Diabetic Mice
by: Nuraliza A.S.; Khairuddin S.A.; Effendi I.; Raudzah A.R.N.; Kadir S.H.S.A.
Published: (2024)

Anti-inflammatory Effects of Astaxanthin Extracted from Microalgae Hematococcus pluvialis and Combinations with Palm Tocotrienol Rich-Fraction in RAW 264.7 Macrophages
by: Radzun K.A.; Rusmidi M.H.H.; Aini M.A.M.; Norisam I.; Iran N.; Pardi F.; Ismail A.; Razak W.; Hafid S.R.A.
Published: (2022)

Different concentrations of nivolumab reduce PD-1 expression but not tumour growth in an EMT6 mouse model
by: Sham, et al.
Published: (2024)

Protective effect of palm oil-derived tocotrienol-rich fraction against retinal neurodegenerative changes in rats with streptozotocin-induced diabetic retinopathy
by: Sadikan M.Z.; Nasir N.A.A.; Agarwal R.; Ismail N.M.
Published: (2020)

Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy
by: Goh Y.; Sadikan M.Z.; Jaiprakash H.; Nasir N.A.A.; Agarwal R.; Iezhitsa I.; Ismail N.M.
Published: (2024)

Comparison study between extrusion and injection molding on cellular structure of PP/PS/PMMA ternary blend foam; [Kajian perbandingan di antara kaedah proses penyemperitan dan proses pengacuan suntikan ke atas struktur sel PP/PS/PMMA campuran pertigaan busar polimer]
by: Sharudin R.W.; Ohshima M.
Published: (2017)

Short-term effects of nitrate-rich beetroot extract supplementation on blood pressure indices and intense intermittent exercise performance in healthy males
by: Saleh M.M.; Linoby A.; Hadi N.I.; Kassim N.A.; Sanuddin N.D.; Razak R.A.; Kasim N.A.A.; Azemi M.A.; Azam M.Z.M.
Published: (2023)

Resveratrol Oligomers from the Twigs of Neobalanocarpus heimii ( King) PS Ashton (Dipterocarpaceae)
by: Zakaria, et al.
Published: (2023)

Tocotrienols and α-tocopherol reduced acute and chronic lung lipid peroxidation induced by paraquat in rats
by: Asmadi A.Y.; Adam A.; Wan Ngah W.Z.; Norazlina M.; Kamisah Y.; Nur-Azlina M.F.; Qodriyah M.S.; Ahmad N.S.; Gapor M.T.; Marzuki A.
Published: (2005)

EFFECTS OF PALM OIL DERIVED TOCOTRIENOL RICH FRACTION AND VITAMIN E ISOMERS ON BIOMARKERS OF EARLY ATHEROGENESIS IN STIMULATED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
by: Muid S.A.; Froemming G.A.R.; Ali A.M.; Rahman T.H.A.; Hamid Z.; Nawawi H.
Published: (2022)

Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells
by: Tan J.-K.; Then S.-M.; Mazlan M.; Raja Abdul Rahman R.N.Z.; Jamal R.; Wan Ngah W.Z.
Published: (2016)

Optical characterization of porous silicon (PS) doped Erbium (Er) using photoluminescence spectroscopy
by: Omar H.; Sabri N.K.; Radzi A.A.S.M.; Rusop M.; Abdullah S.; Ikhsan N.I.
Published: (2014)

Transcriptome analysis reveals the molecular mechanisms of combined gamma-tocotrienol and hydroxychavicol in preventing the proliferation of 1321N1, SW1783, and LN18 glioma cancer cells
by: Abdul Rahman A.; Mokhtar N.M.; Harun R.; Jamal R.; Wan Ngah W.Z.
Published: (2019)

Tocotrienol and physiology of reproduction
by: Rajikin M.H.; Mokhtar N.; Chatterjee A.; Kamsani Y.S.
Published: (2012)

Natural products and chemotaxonomic studies from the twigs of Neobalanocarpus heimii (King) P.S. Ashton (Dipterocarpaceae, Malvales)
by: Zakaria N.S.; Ab'lah N.; Kamarozaman A.S.; Azmin N.F.N.; Azman F.A.I.; Mohamad Yusof M.I.; Saidin S.; Ahmat N.
Published: (2024)

Natural products and chemotaxonomic studies from the twigs of Neobalanocarpus heimii (King) PS Ashton (Dipterocarpaceae, Malvales)
by: Zakaria, et al.
Published: (2024)

Ethanol Extract of Centella asiatica Improved Methamphetamine-Induced Neurotoxicity on Mouse Model via Stimulating Superoxide Dismutase II and microRNA-34A Expression
by: Shamsuddin N.; Zain M.M.; Adenan M.I.; Noorden M.S.A.
Published: (2023)

Optimization of CTLA-4 and PD-1 proteins in EMT6 Mouse Mammary Cancer Cells by Western Blot
by: Sham N.F.R.; Hasani N.A.H.; Idorus M.Y.; Karim M.K.A.; Fuad S.B.S.A.; Hasbullah H.H.; Ibahim M.J.
Published: (2023)

Clinical investigation of the protective effects of palm vitamin e tocotrienols on brain white matter
by: Gopalan Y.; Shuaib I.L.; Magosso E.; Ansari M.A.; Abu Bakar M.R.; Wong J.W.; Khan N.A.K.; Liong W.C.; Sundram K.; Ng B.H.; Karuthan C.; Yuen K.H.
Published: (2014)

A highly sensitive LC-MS/MS method for quantitative determination of 7 vitamin D metabolites in mouse brain tissue
by: Stephenson A.J.; Hunter B.; Shaw P.N.; Kassim N.S.A.; Trengove R.; Takechi R.; Lam V.; Mamo J.
Published: (2023)

Hematological studies in young individuals with Down syndrome
by: Mahamood M.; Hasan M.H.; Alimukhti M.; Sunggip C.; Marzuki A.; Ngah W.Z.W.; Adam A.
Published: (2014)

Tocotrienol preserves ovarian function in cyclophosphamide therapy
by: Saleh H.S.; Omar E.; Froemming G.R.A.; Said R.M.
Published: (2015)

Differential expression of entorhinal cortex and hippocampal subfields α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica
by: Wong J.H.; Muthuraju S.; Reza F.; Senik M.H.; Zhang J.; Mohd Yusuf Yeo N.A.B.; Chuang H.G.; Jaafar H.; Yusof S.R.; Mohamad H.; Tengku Muhammad T.S.; Ismail N.H.; Husin S.S.; Abdullah J.M.
Published: (2019)

Metabolomics Profiling of Age-Associated Metabolites in Malay Population
by: Tan J.K.; Zakaria S.N.A.; Gunasekaran G.; Abdul Sani N.F.; Nasaruddin M.L.; Jaafar F.; Abu Bakar Z.H.; Amir Hamzah A.I.Z.; Nor Aripin K.N.; Mohd Rani M.D.; Noh N.A.; Damanhuri H.A.; Mazlan M.; Makpol S.; Wan Ngah W.Z.
Published: (2023)

Differential gene expression of blood-based ABCA9, CNOT8, SESN1, UCP3, MAP2K1 and DDIT4 in Alzheimer’s disease
by: Samsudin A.Z.; Ramasamy K.; Lim S.M.; Chin A.V.; Tan M.P.; Kamaruzzaman S.B.; Ibrahim B.; Majeed A.B.A.
Published: (2023)

Physicochemical and biocompatibility characterisation of a 3D lyophilised platelet-rich fibrin scaffold for cleft lip and palate repair
by: Ngah, et al.
Published: (2024)