Antinociceptive Activity of Petroleum Ether Fraction of Clinacanthus nutans Leaves Methanolic Extract: Roles of Nonopioid Pain Modulatory Systems and Potassium Channels

QR Code

Antinociceptive Activity of Petroleum Ether Fraction of Clinacanthus nutans Leaves Methanolic Extract: Roles of Nonopioid Pain Modulatory Systems and Potassium Channels

Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been reported to exert antinociceptive activity. The present study aimed to elucidate the possible antinociceptive mechanisms of a lipid-soluble fraction of MECN, which was obtained after sequential extraction in petroleum ether. The...

Full description

Bibliographic Details
Published in:	BioMed Research International
Main Author:	Zakaria Z.A.; Abdul Rahim M.H.; Roosli R.A.J.; Mohd Sani M.H.; Marmaya N.H.; Omar M.H.; Teh L.K.; Salleh M.Z.
Format:	Article
Language:	English
Published:	Hindawi Limited 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071190637&doi=10.1155%2f2019%2f6593125&partnerID=40&md5=36faa004796ed89b0f6960da5f626e12

Similar Items

Antinociceptive Activity of Methanolic Extract of Clinacanthus nutans Leaves: Possible Mechanisms of Action Involved
by: Zakaria Z.A.; Abdul Rahim M.H.; Roosli R.A.J.; Mohd Sani M.H.; Omar M.H.; Tohid S.F.; Othman F.; Ching S.M.; Abdul Kadir A.
Published: (2018)

Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway
by: Zakaria Z.A.; Abdul Rahim M.H.; Mohd Sani M.H.; Omar M.H.; Ching S.M.; Abdul Kadir A.; Ahmed Q.U.
Published: (2019)

Methanolic extract of clinacanthus nutans exerts antinociceptive activity via the opioid/nitric oxide-mediated, but cGMP-independent, pathways
by: Abdul Rahim M.H.; Zakaria Z.A.; Mohd Sani M.H.; Omar M.H.; Yakob Y.; Cheema M.S.; Ching S.M.; Ahmad Z.; Abdul Kadir A.
Published: (2016)

Methanol extract of Dicranopteris linearis leaves attenuate pain via the modulation of opioid/NO-mediated pathway
by: Zakaria Z.A.; Roosli R.A.J.; Marmaya N.H.; Omar M.H.; Basir R.; Somchit M.N.
Published: (2020)

Antinociception of petroleum ether fraction derived from crude methanol extract of Melastoma malabathricum leaves and its possible mechanisms of action in animal models
by: Zakaria Z.A.; Jaios E.S.; Omar M.H.; Abd. Rahman S.; Hamid S.S.A.; Ching S.M.; Teh L.K.; Salleh M.Z.; Deny S.; Taher M.
Published: (2016)

Acute and sub-chronic oral toxicity studies of methanol extract of clinacanthus nutans in mice
by: Zakaria Z.A.; Rahim M.H.A.; Mohtarrudin N.; Kadir A.A.; Cheema M.S.; Ahmad Z.; Mooi C.S.; Tohid S.F.M.
Published: (2016)

Surface sterilization method for reducing contamination of Clinacanthus nutans nodal explants intended for in-vitro culture
by: Hashim S.N.; Ghazali S.Z.; Sidik N.J.; Chia-Chay T.; Saleh A.
Published: (2021)

Extraction of phytocompounds from the medicinal plant Clinacanthus nutans Lindau by microwave-assisted extraction and supercritical carbon dioxide extraction
by: Mustapa A.N.; Martin Á.; Mato R.B.; Cocero M.J.
Published: (2015)

Mitragynine and its potential blocking effects on specific cardiac potassium channels
by: Tay Y.L.; Teah Y.F.; Chong Y.M.; Jamil M.F.A.; Kollert S.; Adenan M.I.; Wahab H.A.; Döring F.; Wischmeyer E.; Tan M.L.
Published: (2016)

Molecular docking and molecular dynamic simulations of apoptosis proteins with potential anticancer compounds present in Clinacanthus nutans extract using gas chromatography–mass spectrometry
by: Ismail N.Z.; Mohamed W.A.S.; Ab. Rahim N.; Hashim N.M.; Adebayo I.A.; Mohamad Zain N.N.; Arsad H.
Published: (2023)

Mechanisms of α-Mangostin-Induced Antinociception in a Rodent Model
by: Mohd. Sani M.H.; Taher M.; Susanti D.; Kek T.L.; Salleh M.Z.; Zakaria Z.A.
Published: (2015)

Antioxidant, anti-inflammatory and antinociceptive activities of Mitragyna speciosa and Erythroxylum cuneatum
by: Saleh S.R.; Hasan M.H.; Said M.I.M.; Adenan M.I.; Adam A.
Published: (2012)

Antimicrobial efficacy, antioxidant profile and nine alternative active constituents from petroleum ether and ethyl acetate extract of entada spiralis; [Keberkesanan antimikrob, profil antioksida dan sembilan komponen alternatif aktif dari ekstrak petroleum eter dan etil asetat dari pokok entada spiralis]
by: Harun A.; Aziz N.A.; Azenan N.S.M.; Kamarazzaman N.F.M.; Mat So’Ad S.Z.
Published: (2020)

PHYTOCHEMICAL PRODUCTION ENHANCEMENT ON IN VITRO CULTURE OF Clinacathus nutans; [Peningkatan Pengeluaran Fitokimia Pada Kultur In Vitro Clinacathus nutans]
by: Hashim S.N.; Mohamed S.M.; Sidik N.J.; Khotob M.F.M.; Chay T.C.
Published: (2024)

Preliminary analysis of the antinociceptive activity of zerumbone
by: Sulaiman M.R.; Perimal E.K.; Zakaria Z.A.; Mokhtar F.; Akhtar M.N.; Lajis N.H.; Israf D.A.
Published: (2009)

Electrospun strontium cross-linked sulfonated poly (Ether ether ketone) speek nanofiber for proton exchange membrane fuel cell
by: Indong E.S.E.; Sekak K.A.
Published: (2020)

Urinary sodium and potassium excretion, mortality, and cardiovascular events
by: O'Donnell M.; Mente A.; Rangarajan S.; McQueen M.J.; Wang X.; Liu L.; Yan H.; Lee S.F.; Mony P.; Devanath A.; Rosengren A.; Lopez-Jaramillo P.; Diaz R.; Avezum A.; Lanas F.; Yusoff K.; Iqbal R.; Ilow R.; Mohammadifard N.; Gulec S.; Yusufali A.H.; Kruger L.; Yusuf R.; Chifamba J.; Kabali C.; Dagenais G.; Lear S.A.; Teo K.; Yusuf S.
Published: (2014)

Synthesis of smoke signal with potassium nitrate (KNO3) as the oxidizer
by: Subuki I.; Salleh Z.; Molinka M.; Hamid A.H.A.; Rahman N.F.A.
Published: (2024)

Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves
by: Jaios E.S.; Rahman S.; Ching S.M.; Kadir A.A.; Desa M.N.M.; Zakaria Z.A.
Published: (2016)

A Global Research Trend on Endolysosomal Calcium Two-Pore Channels via Bibliometric Analysis
by: Sediqi N.; Jahidin A.H.; Hasan M.H.
Published: (2024)

Assessment of contaminants in sand production from petroleum wells offshore Sabah
by: Shayuti M.S.M.; Zainal S.; Ya T.M.Y.S.T.; Abdullah M.Z.; Shahruddin M.Z.; Othman N.H.; Alias N.H.; Mohd T.A.T.; Sharudin R.W.
Published: (2023)

Association of Piriformis Thickness, Hip Muscle Strength, and Low Back Pain Patients with and without Piriformis Syndrome in Malaysia
by: Othman I.K.; Raj N.B.; Siew Kuan C.; Sidek S.; Wong L.S.; Djearamane S.; Loganathan A.; Selvaraj S.
Published: (2023)

Potassium permanganate (KMnO4) sensing based on microfiber sensors
by: Irawati N.; Yusuf N.A.M.; Rahman H.A.; Yasin M.; Ahmad H.; Harun S.W.
Published: (2017)

Mechanical Properties of Green and Petroleum based Polyurethane as Grouting Materials
by: Hussain N.I.A.M.; Bonnia N.N.; Asli N.A.; Ali E.S.; Hassan N.A.; Affandi N.D.N.
Published: (2022)

Synthesis, in vitro and Docking Studies of New Flavone Ethers as α-Glucosidase Inhibitors
by: Imran S.; Taha M.; Ismail N.H.; Kashif S.M.; Rahim F.; Jamil W.; Wahab H.; Khan K.M.
Published: (2016)

Crystallinity and morphological evolution of hydrothermally synthesized potassium manganese oxide nanowires
by: Haris M.F.L.; Yin C.-Y.; Jiang Z.-T.; Goh B.-M.; Chen X.; Al-Masry W.A.; Abukhalaf A.M.; El-Harbawi M.; Huang N.M.; Lim H.N.
Published: (2014)

Antinociceptive activity of methanolic extract of Muntingia calabura leaves: Further elucidation of the possible mechanisms
by: Zakaria Z.A.; Sani M.H.M.; Cheema M.S.; Kader A.A.; Kek T.L.; Salleh M.Z.
Published: (2014)

Effect of Bleaching with Potassium Hydroxide on the Properties of Egg Carton Pulp for Nitrocellulose Production
by: Andok A.; Lee S.H.; Gilbert Jesuet M.S.; Palle I.
Published: (2023)

Simulation on the Effect of Channel Thickness on the Performance of Multi-Bridge Channel Field-Effect Transistor
by: Xin T.M.; Sultan S.M.; Hussin H.
Published: (2023)

Isolation of potential total petroleum hydrocarbon degraders from river sediments
by: Yun C.T.S.; Huap A.C.
Published: (2010)

Hydraulic and morphological patterns in a riparian vegetated sandy compound straight channel
by: Jumain M.; Ibrahim Z.; Ismail Z.; Jamal M.H.; Rashid M.F.A.; Salleh M.Z.M.; Shariff M.E.M.; Zulkifli N.S.
Published: (2021)

Growth and anatomical responses in Xanthostemon chrysanthus as influenced by paclobutrazol and potassium nitrate
by: Nazarudin M.R.A.; Tsan F.Y.; Normaniza O.; Adzmi Y.
Published: (2015)

Determination of optimum levels of nitrogen, phosphorus and potassium of oil palm seedlings in solution culture
by: Mohidin H.; Hanafi M.M.; Rafii Y.M.; Abdullah S.N.A.; Idris A.S.; Man S.; Idris J.; Sahebi M.
Published: (2015)

In vivo antinociceptive and anti-inflammatory activities of dried and fermented processed virgin coconut oil
by: Zakaria Z.A.; Somchit M.N.; Mat Jais A.M.; Teh L.K.; Salleh M.Z.; Long K.
Published: (2011)

Kinetic and Thermodynamic Studies of Transesterification Catalysed by Black Pepper Seed-Potassium Hydroxide Catalyst
by: Tan Y.Z.; Tan Y.H.; Kansedo J.; Mubarak N.M.; Chin B.L.F.; Karri R.R.; Ibrahim M.L.; Yek P.N.Y.
Published: (2024)

Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models
by: Zakaria Z.A.; Abdul Ghani Z.D.F.; Raden Mohd. Nor R.N.S.; Gopalan H.K.; Sulaiman M.R.; Mat Jais A.M.; Somchit M.N.; Kader A.A.; Ripin J.
Published: (2008)

Evaluation of ethyl lactate as solvent in Fenton oxidation for the remediation of total petroleum hydrocarbon (TPH)-contaminated soil
by: Jalilian Ahmadkalaei S.P.; Gan S.; Ng H.K.; Abdul Talib S.
Published: (2017)

Optimizing the Retention and Leaching of Potassium of Tropical Mineral Acid Soils with Application of Charcoal and Sago Bark Ash
by: Paramisparam P.; Ahmed O.H.; Omar L.; Johan P.D.; Hamidi N.H.; Ch’ng H.Y.; Musah A.A.
Published: (2024)

Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE): A Case-Control Study
by: Judge C.; O'Donnell M.J.; Hankey G.J.; Rangarajan S.; Chin S.L.; Rao-Melacini P.; Ferguson J.; Smyth A.; Xavier D.; Lisheng L.; Zhang H.; Lopez-Jaramillo P.; Damasceno A.; Langhorne P.; Rosengren A.; Dans A.L.; Elsayed A.; Avezum A.; Mondo C.; Ryglewicz D.; Czlonkowska A.; Pogosova N.; Weimar C.; Diaz R.; Yusoff K.; Yusufali A.; Oguz A.; Wang X.; Lanas F.; Ogah O.S.; Ogunniyi A.; Iversen H.K.; Malaga G.; Rumboldt Z.; Oveisgharan S.; Al Hussain F.; Yusuf S.
Published: (2021)

Kinetic and Thermodynamic Studies of Transesterification Catalysed by Black Pepper Seed-Potassium Hydroxide Catalyst
by: Tan, et al.
Published: (2023)