Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits

Background: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the prese...

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Published in:BMC Complementary and Alternative Medicine
Main Author: Sh Ahmed A.; Taher M.; Mandal U.K.; Jaffri J.M.; Susanti D.; Mahmood S.; Zakaria Z.A.
Format: Article
Language:English
Published: BioMed Central Ltd. 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071119875&doi=10.1186%2fs12906-019-2625-2&partnerID=40&md5=77e41fe5c5e483d1fac4a0280de70fd3
id 2-s2.0-85071119875
spelling 2-s2.0-85071119875
Sh Ahmed A.; Taher M.; Mandal U.K.; Jaffri J.M.; Susanti D.; Mahmood S.; Zakaria Z.A.
Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
2019
BMC Complementary and Alternative Medicine
19
1
10.1186/s12906-019-2625-2
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071119875&doi=10.1186%2fs12906-019-2625-2&partnerID=40&md5=77e41fe5c5e483d1fac4a0280de70fd3
Background: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the present study was performed to examine in vivo efficacy of asiaticoside-rich hydrogel formulation in rabbits. Methods: Asiaticoside-rich fraction was prepared from C. asiatica aerial part and then incorporated into polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogel. The hydrogel was subjected to wound healing investigation using the in vivo incision model. Results: The results obtained demonstrated that: i) the hydrogel formulation did not cause any signs of irritation on the rabbits' skin and; ii) enhanced wound healing 15% faster than the commercial cream and > 40% faster than the untreated wounds. The skin healing process was seen in all wounds marked by formation of a thick epithelial layer, keratin, and moderate formation of granulation tissues, fibroblasts and collagen with no fibrinoid necrosis detected. Conclusion: The asiaticoside-rich hydrogel developed using the freeze-thaw method was effective in accelerating wound healing in rabbits. © 2019 The Author(s).
BioMed Central Ltd.
14726882
English
Article
All Open Access; Gold Open Access
author Sh Ahmed A.; Taher M.; Mandal U.K.; Jaffri J.M.; Susanti D.; Mahmood S.; Zakaria Z.A.
spellingShingle Sh Ahmed A.; Taher M.; Mandal U.K.; Jaffri J.M.; Susanti D.; Mahmood S.; Zakaria Z.A.
Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
author_facet Sh Ahmed A.; Taher M.; Mandal U.K.; Jaffri J.M.; Susanti D.; Mahmood S.; Zakaria Z.A.
author_sort Sh Ahmed A.; Taher M.; Mandal U.K.; Jaffri J.M.; Susanti D.; Mahmood S.; Zakaria Z.A.
title Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
title_short Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
title_full Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
title_fullStr Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
title_full_unstemmed Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
title_sort Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
publishDate 2019
container_title BMC Complementary and Alternative Medicine
container_volume 19
container_issue 1
doi_str_mv 10.1186/s12906-019-2625-2
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071119875&doi=10.1186%2fs12906-019-2625-2&partnerID=40&md5=77e41fe5c5e483d1fac4a0280de70fd3
description Background: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the present study was performed to examine in vivo efficacy of asiaticoside-rich hydrogel formulation in rabbits. Methods: Asiaticoside-rich fraction was prepared from C. asiatica aerial part and then incorporated into polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogel. The hydrogel was subjected to wound healing investigation using the in vivo incision model. Results: The results obtained demonstrated that: i) the hydrogel formulation did not cause any signs of irritation on the rabbits' skin and; ii) enhanced wound healing 15% faster than the commercial cream and > 40% faster than the untreated wounds. The skin healing process was seen in all wounds marked by formation of a thick epithelial layer, keratin, and moderate formation of granulation tissues, fibroblasts and collagen with no fibrinoid necrosis detected. Conclusion: The asiaticoside-rich hydrogel developed using the freeze-thaw method was effective in accelerating wound healing in rabbits. © 2019 The Author(s).
publisher BioMed Central Ltd.
issn 14726882
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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