Synthesis, anticancer, molecular docking and QSAR studies of benzoylhydrazone

• Published in: Journal of Saudi Chemical Society
• Main Author: Taha M.; Sultan S.; Herizal M.; Fatmi M.Q.; Selvaraj M.; Ramasamy K.; Halim S.A.; Lim S.M.; Rahim F.; Ashraf K.; Shehzad A.
• Format: Article
• Language: English
• Published: Elsevier B.V. 2019
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070903941&doi=10.1016%2fj.jscs.2019.07.007&partnerID=40&md5=84436723d6a88e0bb60fa0cb2fd7ef25

To find out effective anticancer compounds we synthesized (1–30) derivatives of 4-isopropylbenzoylhydrazone and evaluated for anticancer potential. The compounds 3, 9, 12, 23, 26 and 28 showed better activities ranging (0.39–1.1 µg/ml) than the standard (1.53 ± 0.01 µg/ml). In line with this, compounds 2, 6, 24, 25 and 29 exhibited better activities compared to the second standard (5FU 4.60 ± 0.01 µg/ml). The best molecular docked complex between the BRCA1 structure and the 1–30 derivatives were analyzed based on the Glide docked score and binding orientation for both the SP and XP mode. The 2D-QSAR analysis reflected a significant correlation between the experimental and the predicted biological activities. The above-mentioned compounds were also assessed by various spectroscopic techniques. © 2019 King Saud University