Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA

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Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA

The search of novel mPGES-1 inhibitors has recently intensified probably due to the superior safety in comparison to existing anti-inflammatory drugs. Although two mPGES-1 inhibitors have entered clinical trials, none has yet reached the market. In this study, we performed modifications guided by 3D...

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Bibliographic Details
Published in:	Journal of Molecular Structure
Main Author:	Fasihi Mohd Aluwi M.F.; Rullah K.; Koeberle A.; Werz O.; Abdul Razak N.S.; Wei L.S.; Salim F.; Ismail N.H.; Jantan I.; Wai L.K.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068541933&doi=10.1016%2fj.molstruc.2019.07.004&partnerID=40&md5=a8f9af07b3f06b63d29ebfa5a1b11e4b

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