Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA
The search of novel mPGES-1 inhibitors has recently intensified probably due to the superior safety in comparison to existing anti-inflammatory drugs. Although two mPGES-1 inhibitors have entered clinical trials, none has yet reached the market. In this study, we performed modifications guided by 3D...
| Published in: | Journal of Molecular Structure |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier B.V.
2019
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068541933&doi=10.1016%2fj.molstruc.2019.07.004&partnerID=40&md5=a8f9af07b3f06b63d29ebfa5a1b11e4b |