Molecular Modeling-Based Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells

QR Code

Molecular Modeling-Based Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells

Several studies have shown that the mammalian target of rapamycin (mTOR) inhibitor; everolimus (EV) improves patient survival in several types of cancer. However, the meaningful efficacy of EV as a single agent for the treatment of colorectal cancer (CRC) has failed to be proven in multiple clinical...

Full description

Bibliographic Details
Published in:	ACS Omega
Main Author:	Maki M.A.A.; Kumar P.V.; Cheah S.-C.; Siew Wei Y.; Al-Nema M.; Bayazeid O.; Majeed A.B.B.A.
Format:	Article
Language:	English
Published:	American Chemical Society 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066960433&doi=10.1021%2facsomega.9b00109&partnerID=40&md5=4bcb43e34dd07537585b3109737c377c

Similar Items

Bifidobacterium pseudocatenulatum ATCC 27919 exopolysaccharides induced autophagy and apoptosis against endoplasmic reticulum stress in Caco-2 cells
by: Zulkipli H.; Yaziz H.N.M.; Idorus M.Y.; Kadir S.H.S.A.; Musa M.; Khalil K.A.
Published: (2023)

Molecular mechanism of allicin-induced apoptosis in human oral squamous cell carcinoma (OSCC)
by: Hazwani F.; Amin I.M.; Rahim M.A.A.
Published: (2022)

Benzimidazole derivatives protect against cytokine-induced apoptosis in pancreatic β-Cells
by: Zawawi N.K.N.A.; Rajput S.A.; Taha M.; Ahmat N.; Ismail N.H.; Abdullah N.; Khan K.M.; Choudhary M.I.
Published: (2015)

Production of bioplastic from cassava peel with different concentrations of glycerol and CaCO3 as filler
by: Abidin N.D.Z.; Azhar N.S.; Sarip M.N.; Hamid H.A.; Nasir N.A.H.A.
Published: (2021)

Severe hyperthermia induces apoptosis mediated by caspases activation and suppression of Hsp90α expression in osteosarcoma cells
by: Nashiry M.A.; Froemming G.R.A.; Keong Y.S.; Ismail A.B.M.; Din A.M.; Al-Khateeb A.M.
Published: (2019)

COMPARATIVE EFFECT OF RHIZOSPHERIC AND ENDOPHYTIC BACTERIA ON TCP AND CaCO3 SOLUBILIZATION AND GROWTH PROMOTION OF WHEAT (TRITICUM AESTIVUM L.)
by: Javed S.; Mazhar M.W.; Yusof N.Y.; Rehan M.B.M.; Hanaphi R.M.; Ahmad N.S.-H.N.; Yaakob A.S.; Harun H.C.; Aziz T.; Alharbi M.; Alasmari A.F.
Published: (2024)

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells
by: Aziz M.Y.A.; Omar A.R.; Subramani T.; Yeap S.K.; Ho W.Y.; Ismail N.H.; Ahmad S.; Alitheen N.B.
Published: (2014)

Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells
by: Tan J.-K.; Then S.-M.; Mazlan M.; Raja Abdul Rahman R.N.Z.; Jamal R.; Wan Ngah W.Z.
Published: (2016)

Molecular docking and molecular dynamic simulations of apoptosis proteins with potential anticancer compounds present in Clinacanthus nutans extract using gas chromatography–mass spectrometry
by: Ismail N.Z.; Mohamed W.A.S.; Ab. Rahim N.; Hashim N.M.; Adebayo I.A.; Mohamad Zain N.N.; Arsad H.
Published: (2023)

Aloe emodin induces apoptosis in ER+-breast cancer cells; MCF-7 through IGF-1R signalling pathway
by: Amin I.M.; Kamaludin R.; Yeap S.K.; Isa M.R.; Mohd Rosdy N.M.M.N.; Siran R.; Kadir S.H.S.A.; Hasani N.A.H.
Published: (2015)

Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy
by: Goh Y.; Sadikan M.Z.; Jaiprakash H.; Nasir N.A.A.; Agarwal R.; Iezhitsa I.; Ismail N.M.
Published: (2024)

Effect of Temperature and CO2 Flowrate on the Formation of CaCO3 in the Hydration Reaction of CO2 Catalyzed by Immobilized Carbonic anhydrase into PVDF Membrane
by: Abdullah S.N.; Hamzah F.; Husain N.C.; Veny H.; Rodhi M.N.M.; Mohidem N.A.
Published: (2023)

Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery
by: Ramli S.; Wu Y.S.; Batumalaie K.; Guad R.M.; Choy K.W.; Kumar A.; Gopinath S.C.B.; Rahman Sarker M.M.; Subramaniyan V.; Sekar M.; Fuloria N.K.; Fuloria S.; Chinni S.V.; Ramachawolran G.
Published: (2023)

Embryo apoptosis identification: Oocyte grade or cleavage stage?
by: Bakri N.M.; Ibrahim S.F.; Osman N.A.; Hasan N.; Jaffar F.H.F.; Rahman Z.A.; Osman K.
Published: (2016)

Possible role of GABA-B receptor modulation in MPTP induced Parkinson's disease in rats
by: Tyagi R.K.; Bisht R.; Pant J.; kumar P.; Majeed A.B.A.; Prakash A.
Published: (2015)

Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against β-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats
by: Kalra J.; Kumar P.; Majeed A.B.A.; Prakash A.
Published: (2016)

Modulation of the Nitrergic Pathway via Activation of PPAR-γ Contributes to the Neuroprotective Effect of Pioglitazone Against Streptozotocin-Induced Memory Dysfunction
by: Prakash A.; Kumar A.; Ming L.C.; Mani V.; Majeed A.B.A.
Published: (2015)

Mitigation of H 2O 2 -induced mitochondrial-mediated apoptosis in NG108-15 cells by novel mesuagenin C from Mesua kunstleri (King) kosterm
by: Chan G.; Kamarudin M.N.A.; Wong D.Z.H.; Ismail N.H.; Abdul Latif F.; Hasan A.; Awang K.; Abdul Kadir H.
Published: (2012)

In vitro isolation and molecular identification of reptarenavirus in Malaysia
by: Abba Y.; Hassim H.; Hamzah H.; Ibrahim O.E.; Ilyasu Y.; Bande F.; Mohd Lila M.A.; Noordin M.M.
Published: (2016)

The effect of polyherbal formulation DIA7 on fasting blood glucose level in alloxan induced diabetic rats
by: Mohammed Muneersha T.K.; Fathima Habeeba T.E.; Musambil M.; Mirshad P.V.; Fasalu Rahiman O.M.; Vasudevan M.
Published: (2014)

Heavy Metal Exposure-Induced Cardiovascular Diseases: Molecular Mechanisms and Therapeutic Role of Antioxidants
by: Ponnusamy B.; Veeraraghavan V.P.; Al-Huseini I.; Woon C.K.; Jayaraman S.; Sirasanagandla S.R.
Published: (2024)

Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest
by: Armania N.; Yazan L.S.; Musa S.N.; Ismail I.S.; Foo J.B.; Chan K.W.; Noreen H.; Hisyam A.H.; Zulfahmi S.; Ismail M.
Published: (2013)

Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends
by: Choudhury H.; Pandey M.; Chin P.X.; Phang Y.L.; Cheah J.Y.; Ooi S.C.; Mak K.-K.; Pichika M.R.; Kesharwani P.; Hussain Z.; Gorain B.
Published: (2018)

The role of multifunctional drug therapy against carbamate induced neuronal toxicity during acute and chronic phase in rats
by: Chahal K.S.; Prakash A.; Majeed A.B.A.
Published: (2015)

Performance of alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems
by: Mohd Nordin U.U.; Ahmad N.; Salim N.; Tajuddin H.A.; Abu Bakar N.F.; Narasimhan A.K.
Published: (2023)

Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines
by: Raihan J.; Ahmad U.; Yong Y.K.; Eshak Z.; Othman F.; Ideris A.
Published: (2019)

Strobilanthes crispus juice concentrations and anticancer effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma cells
by: Hussin F.; Eshkoor S.A.; Rahmat A.; Othman F.; Akim A.; Eshak Z.
Published: (2015)

Ion accumulation-induced capacitance elevation in a microporous graphene-based supercapacitor
by: Pattanayak B.; Le P.-A.; Panda D.; Simanjuntak F.M.; Wei K.-H.; Winie T.; Tseng T.-Y.
Published: (2022)

Eurycoma longifolia, a potential phytomedicine for the treatment of cancer: Evidence of p53-mediated apoptosis in cancerous cells
by: Thu H.E.; Hussain Z.; Mohamed I.N.; Shuid A.N.
Published: (2018)

Lactobacilli-fermented cow's milk attenuated lipopolysaccharide-induced neuroinflammation and memory impairment in vitro and in vivo
by: Musa N.H.; Mani V.; Lim S.M.; Vidyadaran S.; Abdul Majeed A.B.; Ramasamy K.
Published: (2017)

Synergistic hepatoprotective potential of ethanolic extract of Solanum xanthocarpum and Juniperus communis against paracetamol and azithromycin induced liver injury in rats
by: Singh H.; Prakash A.; Kalia A.N.; Majeed A.B.A.
Published: (2016)

Implementation of Hexacopter for Package Delivery
by: Suparta W.; Ahmad A.C.; Tharim A.H.A.
Published: (2024)

Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery
by: Kaity S.; Isaac J.; Kumar P.M.; Bose A.; Wong T.W.; Ghosh A.
Published: (2013)

Goniothalamus lanceolatus extract inhibits the growth of human ovarian cancer cells through migration suppression and apoptosis induction
by: Razali N.; Othman N.; Ismail N.H.; Bihud N.V.; Ismail N.H.; Yusof F.Z.M.
Published: (2021)

Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231
by: Rahman N.A.; Yazan L.S.; Wibowo A.; Ahmat N.; Foo J.B.; Tor Y.S.; Yeap S.K.; Razali Z.A.; Ong Y.S.; Fakurazi S.
Published: (2016)

Colostrum supplementation protects against exercise - Induced oxidative stress in skeletal muscle in mice
by: Appukutty M.; Radhakrishnan A.K.; Ramasamy K.; Ramasamy R.; Abdul Majeed A.B.; Noor M.I.; Safii N.S.; Koon P.B.; Chinna K.; Haleagrahara N.
Published: (2012)

Design and development of novel hyaluronate-modified nanoparticles for combo-delivery of curcumin and alendronate: fabrication, characterization, and cellular and molecular evidences of enhanced bone regeneration
by: Dong J.; Tao L.; Abourehab M.A.S.; Hussain Z.
Published: (2018)

Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery
by: Al-Ani S.A.; Lee Q.Y.; Maheswaran D.; Sin Y.M.; Loh J.S.; Foo J.B.; Hamzah S.; Ng J.F.; Tan L.K.S.
Published: (2024)

Chemoprevention by Microencapsulated Lactiplantibacillus Plantarum LAB12 Against Orthotopic Colorectal Cancer Mice is Associated with Apoptosis and Anti-angiogenesis
by: Fareez I.M.; Lim S.M.; Ramasamy K.
Published: (2024)

Design and Development of Levodopa Loaded Polymeric Nanoparticles for Intranasal Delivery
by: Ahmad M.Z.; Sabri A.H.B.; Anjani Q.K.; Domínguez-Robles J.; Abdul Latip N.; Hamid K.A.
Published: (2022)