Gabapentin completely neutralized the acute morphine activation in the rat hypothalamus: A c-Fos study

Aim: The molecular mechanism of gabapentin (GBP)-morphine combinational function and its neuro-Anatomical sites of action to prevent, to neutralize morphine side effects and also the enhancement its analgesic effect of morphine is unknown. Methods: Morphine (10 mg/kg), saline, co-injection: GBP (150...

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Bibliographic Details
Published in:Future Neurology
Main Author: Kazi J.A.; Zatilfarihiah R.
Format: Article
Language:English
Published: Future Medicine Ltd. 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066792413&doi=10.2217%2ffnl-2018-0037&partnerID=40&md5=de05e672255e56354d67b79a275be068
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Summary:Aim: The molecular mechanism of gabapentin (GBP)-morphine combinational function and its neuro-Anatomical sites of action to prevent, to neutralize morphine side effects and also the enhancement its analgesic effect of morphine is unknown. Methods: Morphine (10 mg/kg), saline, co-injection: GBP (150 mg/kg) with morphine (10 mg/kg) were injected by intraperitoneal injection in rats under deep anaesthesia. C-Fos immunohistochemistry technique was used to locate c-Fos expression in rat hypothalamus. Results: Gabapentin in combination with morphine significantly (p < 0.01) attenuated the acute morphine induced c-Fos immunoreactive neuron in hypothalamus. Conclusion: GBP neutralized the morphine sensitization in rat hypothalamus. GBP might neuromodulate and or antagonize the receptor regulatory machinery of morphine sensitization circuit which might work for drug discovery of morphine abuse. © 2019 Kazi Ahsan Jamil.
ISSN:14796708
DOI:10.2217/fnl-2018-0037