Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives

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Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives

Isoquinoline analogues (KA-1 to 16) have been synthesized and evaluated for their E. coli thymidine phosphorylase inhibitory activity. Except compound 11, all other analogs showed outstanding thymidine inhibitory potential ranging in between 4.40 ± 0.20 to 69.30 ± 1.80 µM when compared with standard...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Zaman K.; Rahim F.; Taha M.; Wadood A.; Adnan Ali Shah S.; Gollapalli M.; Ullah F.; Ahmed A.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066282970&doi=10.1016%2fj.bioorg.2019.102999&partnerID=40&md5=b49a72ea77f2bff64cf00a1aaf278f15

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