The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review

Low-density lipoprotein receptor (LDLR) has been an object of research since the 1970s because of its role in various cell functions. The LDLR family members include LRP5, LRP6, and LRP8. Even though LRP5, 6, and 8 are in the same family, intriguingly, these three proteins have various roles in phys...

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Published in:Journal of Oncology
Main Author: Roslan Z.; Muhamad M.; Selvaratnam L.; Ab-Rahim S.
Format: Review
Language:English
Published: Hindawi Limited 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064255664&doi=10.1155%2f2019%2f4536302&partnerID=40&md5=d48e4f751ffa71b1db70e6e6ddd3857e
id 2-s2.0-85064255664
spelling 2-s2.0-85064255664
Roslan Z.; Muhamad M.; Selvaratnam L.; Ab-Rahim S.
The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review
2019
Journal of Oncology
2019

10.1155/2019/4536302
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064255664&doi=10.1155%2f2019%2f4536302&partnerID=40&md5=d48e4f751ffa71b1db70e6e6ddd3857e
Low-density lipoprotein receptor (LDLR) has been an object of research since the 1970s because of its role in various cell functions. The LDLR family members include LRP5, LRP6, and LRP8. Even though LRP5, 6, and 8 are in the same family, intriguingly, these three proteins have various roles in physiological events, as well as in regulating different mechanisms in various kinds of cancers. LRP5, LRP6, and LRP8 have been shown to play important roles in a broad panel of cancers. LRP5 is highly expressed in many tissues and is involved in the modulation of glucose-induced insulin secretion, bone development, and cholesterol metabolism, as well as cancer progression. Recently, LRP5 has also been shown to play a role in chondroblastic subtype of osteosarcoma (OS) and prostate cancer and also in noncancer case such as osteoporosis. LRP6, which has been previously discovered to share the same structures as LRP5, has also been associated with many cancer progressions such as human triple negative breast cancer (TNBC), primary chronic lymphocytic leukemia (CLL), nonsmall cell lung cancer (NSCL), lung squamous cell carcinoma (LSCC), and hepatocellular carcinoma (HCC). In addition to its role in cancer progression, LRP8 (apolipoprotein E receptor 2 [APOER2]) has also been demonstrated to regulate canonical Wnt/β-catenin signaling pathway whereby this pathway plays a role in cell migration and development. Therefore, this review aimed to elucidate the role of LRP 5, 6, and 8 in regulating the cancer progression. © 2019 Zulaika Roslan et al.
Hindawi Limited
16878450
English
Review
All Open Access; Gold Open Access
author Roslan Z.; Muhamad M.; Selvaratnam L.; Ab-Rahim S.
spellingShingle Roslan Z.; Muhamad M.; Selvaratnam L.; Ab-Rahim S.
The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review
author_facet Roslan Z.; Muhamad M.; Selvaratnam L.; Ab-Rahim S.
author_sort Roslan Z.; Muhamad M.; Selvaratnam L.; Ab-Rahim S.
title The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review
title_short The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review
title_full The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review
title_fullStr The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review
title_full_unstemmed The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review
title_sort The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review
publishDate 2019
container_title Journal of Oncology
container_volume 2019
container_issue
doi_str_mv 10.1155/2019/4536302
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064255664&doi=10.1155%2f2019%2f4536302&partnerID=40&md5=d48e4f751ffa71b1db70e6e6ddd3857e
description Low-density lipoprotein receptor (LDLR) has been an object of research since the 1970s because of its role in various cell functions. The LDLR family members include LRP5, LRP6, and LRP8. Even though LRP5, 6, and 8 are in the same family, intriguingly, these three proteins have various roles in physiological events, as well as in regulating different mechanisms in various kinds of cancers. LRP5, LRP6, and LRP8 have been shown to play important roles in a broad panel of cancers. LRP5 is highly expressed in many tissues and is involved in the modulation of glucose-induced insulin secretion, bone development, and cholesterol metabolism, as well as cancer progression. Recently, LRP5 has also been shown to play a role in chondroblastic subtype of osteosarcoma (OS) and prostate cancer and also in noncancer case such as osteoporosis. LRP6, which has been previously discovered to share the same structures as LRP5, has also been associated with many cancer progressions such as human triple negative breast cancer (TNBC), primary chronic lymphocytic leukemia (CLL), nonsmall cell lung cancer (NSCL), lung squamous cell carcinoma (LSCC), and hepatocellular carcinoma (HCC). In addition to its role in cancer progression, LRP8 (apolipoprotein E receptor 2 [APOER2]) has also been demonstrated to regulate canonical Wnt/β-catenin signaling pathway whereby this pathway plays a role in cell migration and development. Therefore, this review aimed to elucidate the role of LRP 5, 6, and 8 in regulating the cancer progression. © 2019 Zulaika Roslan et al.
publisher Hindawi Limited
issn 16878450
language English
format Review
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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