Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population

Synthesized 2D images can be reconstructed from tomosynthesis images in breast imaging. This study aims to investigate the diagnostic efficacy of synthesized 2D images (C-View) in comparison to full field digital mammography (FFDM) when used with digital breast tomosynthesis (DBT) in multi-ethnic Ma...

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Published in:Scientific Reports
Main Author: Mumin N.A.; Rahmat K.; Fadzli F.; Ramli M.T.; Westerhout C.J.; Ramli N.; Rozalli F.I.; Ng K.H.
Format: Article
Language:English
Published: Nature Publishing Group 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061113033&doi=10.1038%2fs41598-018-37451-4&partnerID=40&md5=4e1cb0cb2a90a87c4664259af37ddef4
id 2-s2.0-85061113033
spelling 2-s2.0-85061113033
Mumin N.A.; Rahmat K.; Fadzli F.; Ramli M.T.; Westerhout C.J.; Ramli N.; Rozalli F.I.; Ng K.H.
Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
2019
Scientific Reports
9
1
10.1038/s41598-018-37451-4
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061113033&doi=10.1038%2fs41598-018-37451-4&partnerID=40&md5=4e1cb0cb2a90a87c4664259af37ddef4
Synthesized 2D images can be reconstructed from tomosynthesis images in breast imaging. This study aims to investigate the diagnostic efficacy of synthesized 2D images (C-View) in comparison to full field digital mammography (FFDM) when used with digital breast tomosynthesis (DBT) in multi-ethnic Malaysian population. FFDM and C-View images (n = 380) were independently evaluated by three readers through Breast Imaging Reporting and Data System (BI-RADS) categorisation, breast density and lesion characterisation. Statistical analysis was done comparing sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of C-View + DBT with FFDM + DBT as standard of reference. Very good interreader agreement in BI-RADS category and density assessment between C-View + DBT and FFDM + DBT, with high sensitivity, specificity, PPV and NPV of C-View + DBT when compared with FFDM + DBT. There was comparable PPV between C-View + DBT and FFDM + DBT, with histopathology as gold standard. High level of interreader agreement in BI-RADS category and density assessment for FFDM + DBT and C-View + DBT. There was good agreement between FFDM + DBT and C-View + DBT in mass characterization, and almost perfect agreement in calcification and asymmetric density. 52.2% lower radiation dose incurred when using C-View + DBT. Hence, synthesized 2D images are comparable to FFDM with reduction in radiation dose within the limits of Malaysian multi-ethnic population. © 2019, The Author(s).
Nature Publishing Group
20452322
English
Article
All Open Access; Gold Open Access
author Mumin N.A.; Rahmat K.; Fadzli F.; Ramli M.T.; Westerhout C.J.; Ramli N.; Rozalli F.I.; Ng K.H.
spellingShingle Mumin N.A.; Rahmat K.; Fadzli F.; Ramli M.T.; Westerhout C.J.; Ramli N.; Rozalli F.I.; Ng K.H.
Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
author_facet Mumin N.A.; Rahmat K.; Fadzli F.; Ramli M.T.; Westerhout C.J.; Ramli N.; Rozalli F.I.; Ng K.H.
author_sort Mumin N.A.; Rahmat K.; Fadzli F.; Ramli M.T.; Westerhout C.J.; Ramli N.; Rozalli F.I.; Ng K.H.
title Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
title_short Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
title_full Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
title_fullStr Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
title_full_unstemmed Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
title_sort Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
publishDate 2019
container_title Scientific Reports
container_volume 9
container_issue 1
doi_str_mv 10.1038/s41598-018-37451-4
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061113033&doi=10.1038%2fs41598-018-37451-4&partnerID=40&md5=4e1cb0cb2a90a87c4664259af37ddef4
description Synthesized 2D images can be reconstructed from tomosynthesis images in breast imaging. This study aims to investigate the diagnostic efficacy of synthesized 2D images (C-View) in comparison to full field digital mammography (FFDM) when used with digital breast tomosynthesis (DBT) in multi-ethnic Malaysian population. FFDM and C-View images (n = 380) were independently evaluated by three readers through Breast Imaging Reporting and Data System (BI-RADS) categorisation, breast density and lesion characterisation. Statistical analysis was done comparing sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of C-View + DBT with FFDM + DBT as standard of reference. Very good interreader agreement in BI-RADS category and density assessment between C-View + DBT and FFDM + DBT, with high sensitivity, specificity, PPV and NPV of C-View + DBT when compared with FFDM + DBT. There was comparable PPV between C-View + DBT and FFDM + DBT, with histopathology as gold standard. High level of interreader agreement in BI-RADS category and density assessment for FFDM + DBT and C-View + DBT. There was good agreement between FFDM + DBT and C-View + DBT in mass characterization, and almost perfect agreement in calcification and asymmetric density. 52.2% lower radiation dose incurred when using C-View + DBT. Hence, synthesized 2D images are comparable to FFDM with reduction in radiation dose within the limits of Malaysian multi-ethnic population. © 2019, The Author(s).
publisher Nature Publishing Group
issn 20452322
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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