Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and computational contemplations

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Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and computational contemplations

Keeping in mind the pharmacological importance of 2-aminothiazole and 1,2,4-triazole heterocyclic moieties, a series of novel ethylated bi-heterocyclic acetamide hybrids, 9a–p, was synthesized in a multi-step protocol. The structures of newly synthesized compounds were c...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Butt A.R.S.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Raza H.; Shah S.A.A.; Seo S.-Y.
Format:	Review
Language:	English
Published:	Academic Press Inc. 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060856533&doi=10.1016%2fj.bioorg.2019.01.040&partnerID=40&md5=b1b89e8217b618d2cfdce588785cad50

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