Antiplasmodial anthraquinones from medicinal plants: The chemistry and possible mode of actions

• Published in: Natural Product Communications
• Main Author: Osman C.P.; Ismail N.H.
• Format: Article
• Language: English
• Published: Natural Product Incorporation 2018
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059548311&doi=10.1177%2f1934578x1801301207&partnerID=40&md5=b037743b55c4a7c5b59f05f7dfb5c85a

Malaria killed nearly half a million people in 2015, and 70% of this victims were young children. Malarial chemotherapy makes use of several drugs, each with its own pharmacological limitations, and with parasite resistance being the most challenging. People of low income nations often rely on traditional medicine as a treatment due to limited access to modern healthcare services. Despite uncertainties present in the outcome of traditional medicine, ethnomedicine approach has yielded important lead candidates. The investigation of medicinal plants utilized in the malaria endemic region yielded many antiplasmodial compounds with anthraquinone moiety. This paper describes natural anthraquinones extracted from medicinal plants utilized in traditional medicine for the treatment of malaria. In addition, the insight on structure-activity relationship and their mode of actions are also elaborated. Copyright © 2018 Natural Product Incorporation. All rights reserved..