Wound healing properties in Sprague-Dawley rats of marine endophytic fungi extracts

• Published in: Malaysian Applied Biology
• Main Author: Aqilah H.M.; Norhayati A.S.; Siti A.A.
• Format: Article
• Language: English
• Published: Malaysian Society of Applied Biology 2018
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059298649&partnerID=40&md5=6823a28c589f2d07342becab77e580a2

Marine endophytic fungi are known to be profilic source of potential bioactive compounds. The aim of the present study was to investigate wound healing properties of three endophytic fungi extracts (CN, MV and ED) isolated from different seaweeds Gracilaria arcuata Zanardini, Gracilaria coronopifolia J.Agard and Acantophora spicifera (M.Vohl) on second degree burn wound healing. Circular second degree burn wounds were created on the dorsal region of normal rats and treated with silver sulphadianze (SSD) as positive control and Tween 20 only as negative control. This study showed treatment with all extracts increased the rate of wound contraction as compared to control groups. CN extract (48%) was more effective than ED (45%), MV (41%) and SSD (40%) starting on the first day of wound contraction observation. Histopathological findings showed all the extracts enhanced epithelisation and tissue granulation significantly as compared to control group. We demonstrated for the first time in the present study that these marine endophytic fungi extracts showed faster healing on the second degree burn even when compared with SSD (positive control). Results suggest that CN, MV and ED marine endophytic fungi extracts tested in this study could be exploited as a potential source for wound dressing occlusion and tissue repairing. © 2019, Malaysian Society of Applied Biology. All rights reserved.