Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies

QR Code

Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies

New series of quinoline-based thiadiazole analogs (1–20) were synthesized, characterized by EI-MS, 1 H NMR and 13 C NMR. All synthesized compounds were subje...

Full description

Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Almandil N.B.; Taha M.; Rahim F.; Wadood A.; Imran S.; Alqahtani M.A.; Bamarouf Y.A.; Ibrahim M.; Mosaddik A.; Gollapalli M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059245167&doi=10.1016%2fj.bioorg.2018.12.025&partnerID=40&md5=41bb3118210005e5e12be360a1b51696

Similar Items

Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study
by: Taha M.; Imran S.; Alomari M.; Rahim F.; Wadood A.; Mosaddik A.; Uddin N.; Gollapalli M.; Alqahtani M.A.; Bamarouf Y.A.
Published: (2019)

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs
by: Javid M.T.; Rahim F.; Taha M.; Rehman H.U.; Nawaz M.; wadood A.; Imran S.; Uddin I.; Mosaddik A.; Khan K.M.
Published: (2018)

Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies
by: Taha M.; Sultan S.; Imran S.; Rahim F.; Zaman K.; Wadood A.; Ur Rehman A.; Uddin N.; Mohammed Khan K.
Published: (2019)

Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
by: Taha M.; Tariq Javid M.; Imran S.; Selvaraj M.; Chigurupati S.; Ullah H.; Rahim F.; Khan F.; Islam Mohammad J.; Mohammed Khan K.
Published: (2017)

New Quinoline Analogues: As Potential Diabetics Inhibitors and Molecular Docking Study
by: Taha M.; Salahuddin M.; Rahim F.; Imran S.; Hussain S.; Uddin N.; Khan K.M.
Published: (2024)

Thiazole based carbohydrazide derivatives as α-amylase inhibitor and their molecular docking study
by: Taha M.; Irshad M.; Imran S.; Rahim F.; Selvaraj M.; Almandil N.B.; Mosaddik A.; Chigurupati S.; Nawaz F.; Ismail N.H.; Ibrahim M.
Published: (2019)

Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives
by: Taha M.; Noreen T.; Imran S.; Nawaz F.; Chigurupati S.; Selvaraj M.; Rahim F.; Hadiani Ismail N.; Kumar A.; Mosaddik A.; Alghamdi A.M.; Abdulrahman nasser alqahtani Y.; Abdulrahman nasser alqahtani A.
Published: (2019)

Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Ali M.; Rehman A.U.
Published: (2015)

Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives
by: Zaman K.; Rahim F.; Taha M.; Wadood A.; Adnan Ali Shah S.; Gollapalli M.; Ullah F.; Ahmed A.
Published: (2019)

Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues
by: Zaman K.; Rahim F.; Taha M.; Ullah H.; Wadood A.; Nawaz M.; Khan F.; Wahab Z.; Shah S.A.A.; Rehman A.U.; Kawde A.-N.; Gollapalli M.
Published: (2019)

Synthesis and molecular modelling studies of phenyl linked oxadiazole-phenylhydrazone hybrids as potent antileishmanial agents
by: Taha M.; Ismail N.H.; Imran S.; Anouar E.H.; Selvaraj M.; Jamil W.; Ali M.; Kashif S.M.; Rahim F.; Khan K.M.; Adenan M.I.
Published: (2017)

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease
by: Alomari M.; Taha M.; Imran S.; Jamil W.; Selvaraj M.; Uddin N.; Rahim F.
Published: (2019)

Thiadiazole derivatives as New Class of β-glucuronidase inhibitors
by: Salar U.; Taha M.; Ismail N.H.; Khan K.M.; Imran S.; Perveen S.; Wadood A.; Riaz M.
Published: (2016)

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies
by: Taha M.; Ismail N.H.; Khan A.; Shah S.A.A.; Anwar A.; Halim S.A.; Fatmi M.Q.; Imran S.; Rahim F.; Khan K.M.
Published: (2015)

Synthesis of novel inhibitors of β-glucuronidase based on the benzothiazole skeleton and their molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Selvaraj M.; Rahim F.
Published: (2016)

Molecular hybridization conceded exceptionally potent quinolinyl-oxadiazole hybrids through phenyl linked thiosemicarbazide antileishmanial scaffolds: In silico validation and SAR studies
by: Taha M.; Ismail N.H.; Ali M.; Rashid U.; Imran S.; Uddin N.; Khan K.M.
Published: (2017)

Synthesis, in vitro biological analysis and molecular docking studies of new thiadiazole-based thiourea derivatives as dual inhibitors of a-amylase and a-glucosidase
by: Khan I.; Rehman W.; Rahim F.; Hussain R.; Khan S.; Rasheed L.; Alanazi A.S.; Hefnawy M.; Alanazi M.M.; Shah S.A.A.; Taha M.
Published: (2023)

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Riaz M.
Published: (2015)

Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Khan K.M.; Riaz M.
Published: (2016)

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
by: Taha M.; Alshamrani F.J.; Rahim F.; Hayat S.; Ullah H.; Zaman K.; Imran S.; Khan K.M.; Naz F.
Published: (2019)

Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico study
by: Zaman K.; Rahim F.; Taha M.; Sajid M.; Hayat S.; Nawaz M.; Salahuddin M.; Iqbal N.; Khan N.U.; Shah S.A.A.; Farooq R.K.; Bahadar A.; Wadood A.; Khan K.M.
Published: (2021)

Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies
by: Taha M.; Ismail N.H.; Lalani S.; Fatmi M.Q.; Atia-Tul-Wahab; Siddiqui S.; Khan K.M.; Imran S.; Choudhary M.I.
Published: (2015)

Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs
by: Taha M.; Ismail N.H.; Imran S.; Rahim F.; Wadood A.; Khan H.; Ullah H.; Salar U.; Khan K.M.
Published: (2016)

Synthesis and Molecular Docking of New Bis-Thiazolidinone-Based Chalcone Analogs as Effective Inhibitors of Acetylcholinesterase and Butyrylcholinesterase
by: Hussain R.; Rahim F.; Rehman W.; Taha M.; Khan S.; Zaman K.; Adnan Ali Shah S.; Wadood A.; Imran S.; Abdellatif M.H.
Published: (2022)

Synthesis, α-amylase inhibitory potential and molecular docking study of indole derivatives
by: Taha M.; Baharudin M.S.; Ismail N.H.; Imran S.; Khan M.N.; Rahim F.; Selvaraj M.; Chigurupati S.; Nawaz M.; Qureshi F.; Vijayabalan S.
Published: (2018)

Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies
by: Chigurupati S.; Selvaraj M.; Mani V.; Selvarajan K.K.; Mohammad J.I.; Kaveti B.; Bera H.; Palanimuthu V.R.; Teh L.K.; Salleh M.Z.
Published: (2016)

Synthesis, molecular docking and α-glucosidase inhibition of 5-aryl-2-(6′-nitrobenzofuran-2′-yl)-1,3,4-oxadiazoles
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Saad S.M.; Khan K.M.; Nasir A.
Published: (2016)

Isatin based thiosemicarbazide derivatives as potential inhibitor of α-glucosidase, synthesis and their molecular docking study
by: Rahim F.; Taha M.; Iqbal N.; Hayat S.; Qureshi F.; Uddin I.; Zaman K.; Rab A.; Wadood A.; Uddin N.; Nawaz M.; Shah S.A.A.; Khan K.M.
Published: (2020)

Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile
by: Naseer A.; Osra F.A.; Awan A.N.; Imran A.; Hameed A.; Ali Shah S.A.; Iqbal J.; Zakaria Z.A.
Published: (2022)

New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study
by: Rahim F.; Tariq S.; Taha M.; Ullah H.; Zaman K.; Uddin I.; Wadood A.; Khan A.A.; Rehman A.U.; Uddin N.; Zafar S.; Shah S.A.A.
Published: (2019)

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
by: Rahim F.; Zaman K.; Taha M.; Ullah H.; Ghufran M.; Wadood A.; Rehman W.; Uddin N.; Shah S.A.A.; Sajid M.; Nawaz F.; Khan K.M.
Published: (2020)

Synthesis, molecular docking and anti-diabetic studies of novel benzimidazole-pyrazoline hybrid molecules
by: Ibraheem F.; Ahmad M.; Ashfaq U.A.; Aslam S.; Khan Z.A.; Sultan S.
Published: (2020)

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
by: Khan K.M.; Qurban S.; Salar U.; Taha M.; Hussain S.; Perveen S.; Hameed A.; Ismail N.H.; Riaz M.; Wadood A.
Published: (2016)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
by: Taha, et al.
Published: (2024)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
by: Taha M.; Shah S.A.A.; Afifi M.; Imran S.; Sultan S.; Rahim F.; Khan K.M.
Published: (2018)

Oxindole based oxadiazole hybrid analogs: Novel α-glucosidase inhibitors
by: Taha M.; Imran S.; Rahim F.; Wadood A.; Khan K.M.
Published: (2018)

Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies
by: Hussain R.; Rahim F.; Rehman W.; Adnan Ali Shah S.; Khan S.; Khan I.; Rasheed L.; Imran S.; Wadood A.; Abdellatif M.H.
Published: (2023)

New biologically dynamic hybrid pharmacophore triazinoindole-based-thiadiazole as potent α-glucosidase inhibitors: In vitro and in silico study
by: Khan A.A.; Rahim F.; Taha M.; Rehman W.; Iqbal N.; Wadood A.; Ahmad N.; Shah S.A.A.; Ghoneim M.M.; Alshehri S.; Salahuddin M.; Khan K.M.
Published: (2022)

Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study
by: Zaman K.; Rahim F.; Taha M.; Wadood A.; Shah S.A.A.; Ahmed Q.U.; Zakaria Z.A.
Published: (2019)