Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques

Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques

A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized using1 H NMR,13 C NMR, IR, and EI-MS spectroscopic analysis. The intermediate triazole was synthesized through a sequential synthesis of carboxylate and carbohydrazide. The bov...

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Published in:Turkish Journal of Chemistry
Main Author: Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Joondan N.; Taupass A.B.; Rasool S.; Shah S.A.A.
Format: Article
Language:English
Published: TUBITAK 2018
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058948001&doi=10.3906%2fkim-1801-95&partnerID=40&md5=86345cee11c6b3e9a96966805cb22c45
id 2-s2.0-85058948001
spelling 2-s2.0-85058948001
Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Joondan N.; Taupass A.B.; Rasool S.; Shah S.A.A.
Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
2018
Turkish Journal of Chemistry
42
6
10.3906/kim-1801-95
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058948001&doi=10.3906%2fkim-1801-95&partnerID=40&md5=86345cee11c6b3e9a96966805cb22c45
A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized using1 H NMR,13 C NMR, IR, and EI-MS spectroscopic analysis. The intermediate triazole was synthesized through a sequential synthesis of carboxylate and carbohydrazide. The bovine serum albumin (BSA) binding of the newly synthesized 1,2,4-triazole derivatives was evaluated along with thermodynamics, site-selective binding, and synchronous study. The results obtained by BSA binding as well as thermodynamic studies justify that all the compounds show spontaneous interaction with BSA and could be effectively distributed and eliminated from the body. Therefore, the triazole-based analogs might be a useful strategy for designing new drug systems. © TÜBİTAK.
TUBITAK
13000527
English
Article
All Open Access; Bronze Open Access
author Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Joondan N.; Taupass A.B.; Rasool S.; Shah S.A.A.
spellingShingle Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Joondan N.; Taupass A.B.; Rasool S.; Shah S.A.A.
Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
author_facet Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Joondan N.; Taupass A.B.; Rasool S.; Shah S.A.A.
author_sort Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Joondan N.; Taupass A.B.; Rasool S.; Shah S.A.A.
title Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
title_short Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
title_full Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
title_fullStr Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
title_full_unstemmed Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
title_sort Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
publishDate 2018
container_title Turkish Journal of Chemistry
container_volume 42
container_issue 6
doi_str_mv 10.3906/kim-1801-95
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058948001&doi=10.3906%2fkim-1801-95&partnerID=40&md5=86345cee11c6b3e9a96966805cb22c45
description A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized using1 H NMR,13 C NMR, IR, and EI-MS spectroscopic analysis. The intermediate triazole was synthesized through a sequential synthesis of carboxylate and carbohydrazide. The bovine serum albumin (BSA) binding of the newly synthesized 1,2,4-triazole derivatives was evaluated along with thermodynamics, site-selective binding, and synchronous study. The results obtained by BSA binding as well as thermodynamic studies justify that all the compounds show spontaneous interaction with BSA and could be effectively distributed and eliminated from the body. Therefore, the triazole-based analogs might be a useful strategy for designing new drug systems. © TÜBİTAK.
publisher TUBITAK
issn 13000527
language English
format Article
accesstype All Open Access; Bronze Open Access
record_format scopus
collection Scopus
_version_ 1809678484363018240

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