LY294002, a PI3K pathway inhibitor, prevents leptin-induced adverse effects on spermatozoa in Sprague-Dawley rats
This study examined the effects of PI3K and AMPK signalling pathway inhibitors on leptin-induced adverse effects on rat spermatozoa. Sprague-Dawley rats, aged 14–16 weeks, were randomised into control, leptin-, leptin + dorsomorphin (AMPK inhibitor)-, and leptin+LY294002...
Published in: | Andrologia |
---|---|
Main Author: | Md Mokhtar A.H.; Malik I.A.; Abd Aziz N.A.A.; Almabhouh F.A.; Durairajanayagam D.; Singh H.J. |
Format: | Article |
Language: | English |
Published: |
Blackwell Publishing Ltd
2019
|
Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056742909&doi=10.1111%2fand.13196&partnerID=40&md5=d1cd006479ae69b3c0a9241bb757824e |
Similar Items
-
Effects of Profortil® on Leptin-Induced Adverse Effects on Sperm Parameters in Sprague-Dawley Rats
by: Alam Malik I.; Durairajanayagam D.; Henkel R.; Singh H.J.
Published: (2024) -
Adverse effects of leptin on histone-to-protamine transition during spermatogenesis are prevented by melatonin in Sprague-Dawley rats
by: Almabhouh F.A.; Singh H.J.
Published: (2018) -
Effects of Profortil® on Leptin-Induced Adverse Effects on Sperm Parameters in Sprague-Dawley Rats
by: Malik, et al.
Published: (2024) -
Effects of leptin on sperm count and morphology in Sprague-Dawley rats and their reversibility following a 6-week recovery period
by: Almabhouh F.A.; Osman K.; Siti Fatimah I.; Sergey G.; Gnanou J.; Singh H.J.
Published: (2015) -
ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats
by: Ibrahim H.S.; Froemming G.R.A.; Omar E.; Singh H.J.
Published: (2014)