New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy
This review aims to overview and critically analyses recent developments in achieving tumour-specific delivery of anticancer agents, maximizing anticancer efficacy, and mitigating tumour progression and off-target effects. Stemming from critical needs to develop target-specific delivery vehicles in...
Published in: | Artificial Cells, Nanomedicine and Biotechnology |
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2018
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Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056322827&doi=10.1080%2f21691401.2017.1397001&partnerID=40&md5=0de40b2bab78a2c9c5cd8219c4185fc1 |
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2-s2.0-85056322827 Safdar M.H.; Hussain Z.; Abourehab M.A.S.; Hasan H.; Afzal S.; Thu H.E. New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy 2018 Artificial Cells, Nanomedicine and Biotechnology 46 8 10.1080/21691401.2017.1397001 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056322827&doi=10.1080%2f21691401.2017.1397001&partnerID=40&md5=0de40b2bab78a2c9c5cd8219c4185fc1 This review aims to overview and critically analyses recent developments in achieving tumour-specific delivery of anticancer agents, maximizing anticancer efficacy, and mitigating tumour progression and off-target effects. Stemming from critical needs to develop target-specific delivery vehicles in cancer therapy, various hyaluronic acid (HA)-conjugated nanomedicines have been fabricated owing to their biocompatibility, safety, tumour-specific targetability of drugs and genes, and proficient interaction with cluster-determinant-44 (CD44) receptors over-expressed on the surface of tumour cells. HA-based conjugation or surface modulation of anticancer drugs encapsulated nanocarriers have shown promising efficacy against the various types of carcinomas of liver, breast, colorectal, pancreatic, lung, skin, ovarian, cervical, head and neck and gastric. The success of this emerging platform is assessed in achieving the rapid internalization of anticancer payloads into the tumour cells, impeding cancer cells division and proliferation, induction of cancer-specific apoptosis and prevention of metastasis (tumour progression). This review extends detailed insight into the engineering of HA-based nanomedicines, characterization, utilization for the diagnosis or treatment of CD44 over-expressing cancer subtypes and emphasizing the transition of nanomedicines to clinical cancer therapy. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. Taylor and Francis Ltd. 21691401 English Review All Open Access; Bronze Open Access |
author |
Safdar M.H.; Hussain Z.; Abourehab M.A.S.; Hasan H.; Afzal S.; Thu H.E. |
spellingShingle |
Safdar M.H.; Hussain Z.; Abourehab M.A.S.; Hasan H.; Afzal S.; Thu H.E. New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy |
author_facet |
Safdar M.H.; Hussain Z.; Abourehab M.A.S.; Hasan H.; Afzal S.; Thu H.E. |
author_sort |
Safdar M.H.; Hussain Z.; Abourehab M.A.S.; Hasan H.; Afzal S.; Thu H.E. |
title |
New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy |
title_short |
New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy |
title_full |
New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy |
title_fullStr |
New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy |
title_full_unstemmed |
New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy |
title_sort |
New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy |
publishDate |
2018 |
container_title |
Artificial Cells, Nanomedicine and Biotechnology |
container_volume |
46 |
container_issue |
8 |
doi_str_mv |
10.1080/21691401.2017.1397001 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056322827&doi=10.1080%2f21691401.2017.1397001&partnerID=40&md5=0de40b2bab78a2c9c5cd8219c4185fc1 |
description |
This review aims to overview and critically analyses recent developments in achieving tumour-specific delivery of anticancer agents, maximizing anticancer efficacy, and mitigating tumour progression and off-target effects. Stemming from critical needs to develop target-specific delivery vehicles in cancer therapy, various hyaluronic acid (HA)-conjugated nanomedicines have been fabricated owing to their biocompatibility, safety, tumour-specific targetability of drugs and genes, and proficient interaction with cluster-determinant-44 (CD44) receptors over-expressed on the surface of tumour cells. HA-based conjugation or surface modulation of anticancer drugs encapsulated nanocarriers have shown promising efficacy against the various types of carcinomas of liver, breast, colorectal, pancreatic, lung, skin, ovarian, cervical, head and neck and gastric. The success of this emerging platform is assessed in achieving the rapid internalization of anticancer payloads into the tumour cells, impeding cancer cells division and proliferation, induction of cancer-specific apoptosis and prevention of metastasis (tumour progression). This review extends detailed insight into the engineering of HA-based nanomedicines, characterization, utilization for the diagnosis or treatment of CD44 over-expressing cancer subtypes and emphasizing the transition of nanomedicines to clinical cancer therapy. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. |
publisher |
Taylor and Francis Ltd. |
issn |
21691401 |
language |
English |
format |
Review |
accesstype |
All Open Access; Bronze Open Access |
record_format |
scopus |
collection |
Scopus |
_version_ |
1814778508080054272 |