Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity

QR Code

Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity

The aim of the present research work was synthesis of some 2-furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives and to ascertain their antibacterial potential. The cytotoxicity of these molecules was also checked to find out their utility as possible therapeutic agents. The synthesis was initiate...

Full description

Bibliographic Details
Published in:	Pakistan Journal of Pharmaceutical Sciences
Main Author:	Abbasi M.A.; Nazeer M.M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Ahmad I.; Shahid M.; Sarwar M.S.
Format:	Article
Language:	English
Published:	Pakistan Journal of Pharmaceutical Sciences 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055182626&partnerID=40&md5=259dd2e1a8bd5279441a69ff821112fe

Similar Items

Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents
by: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-ul-Ain; Ahmad I.; Malik R.; Lodhi M.A.; Khan F.A.; Shahid M.; Fatima H.
Published: (2017)

Linear synthesis of {4-[(2-Alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones as possible therapeutic agents
by: Abbasi M.A.; Khan W.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Shahid M.; Khan K.M.
Published: (2019)

Synthesis of 3-[4-(2-furoyl)-1-piperazinyl]-N-(substituted)propanamides as promising antibacterial agents with mild cytotoxicity
by: Hussain G.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ahmad I.; Malik R.; Shahid M.; Mushtaq Z.; Shah S.A.A.
Published: (2018)

Synthesis of some new 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides as potent antibacterial agents
by: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Ahmad I.; Shahid M.
Published: (2018)

Synthesis Of Some N-(Un/Substituted-Phenyl)-2-(4-Phenyl-1-Piperazinyl)Acetamides as Possible Antibacterial and Anticancer Agents with Mild Cytotoxicity
by: Abbasi M.A.; Nazir M.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Saleem R.S.Z.; Shahid M.; Mirza B.; Ismail H.
Published: (2022)

N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2022)

Synthesis and structure-activity relationship of 1-[(E)-3-phenyl-2-propenyl] piperazine derivatives as suitable antibacterial agents with mild hemolysis
by: Abbasi M.A.; Nazir M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2019)

Synthesis of some new N-(alkyl/aralkyl)-N-(4-methoxyphenethyl) benzenesulfonamides as antibacterial agents against Escherichia coli
by: Abbasi M.A.; Fatima Z.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Shahid M.; Fatima H.
Published: (2019)

Synthetic N-aralkylated-N-(2,4-dimethylphenyl)benzenesulfonamides: As potent anti-bacterial agents
by: Siddiqui S.Z.; Sarwar A.; Abbasi M.A.; Aziz-Ur-Rehman; Hussain M.; Irshad M.; Shah S.A.A.
Published: (2016)

Synthesis and Molecular Docking Studies of Novel Biheterocyclic Propanamides as Antidiabetic Agents Having Mild Cytotoxicity
by: Abbasi M.A.; Rubab K.; Aziz-Ur-Rehman N.; Siddiqui S.Z.; Hassan M.; Raza H.; Shah S.A.A.; Shahid M.; Kloczkowski A.
Published: (2023)

Synthesis of some N-sulfonated derivatives of 1-[(E)-3-phenyl-2-propenyl]piperazine as suitable antibacterial agents
by: Abbasi M.A.; Ijaz M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Fatima H.
Published: (2020)

Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity
by: Nazir M.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Fatima H.; Iftikhar S.; Saleem R.S.Z.
Published: (2019)

Synthesis, Bacterial biofilm inhibition and cytotoxicity of new N-Alkyl/aralkyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-nitrobenzenesulfonamides
by: Abbasi M.A.; Zeb A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Shahid M.; Fatima H.
Published: (2020)

Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
by: Raza H.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Abbas Q.; Hong H.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2020)

Synthesis, spectral analysis and biological evaluation of N-alkyl/aralkyl/aryl-4-chlorobenzenesulfonamide derivatives
by: Aziz-Ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Mohyuddin A.; Nadeem S.; Shah S.A.A.
Published: (2016)

Synthesis, In Vitro, and In Silico Studies of N-(Substituted-Phenyl)-3-(4-Phenyl-1-Piperazinyl)propanamides as Potent Alkaline Phosphatase Inhibitors
by: Abbasi M.A.; Nazir M.; Aziz-ur-Rehman; Siddiqui S.Z.; Raza H.; Zafar A.; Shah S.A.A.; Shahid M.
Published: (2021)

Synthesis of 2-{[5-(aralkyl/aryl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamides: Novel bi-heterocycles as potential therapeutic agents
by: Ramzan M.S.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Lodhi M.A.; Khan F.A.; Mirza B.
Published: (2018)

Synthesis of promising antibacterial and antifungal agents: 2-[[(4-Chlorophenyl)sulfonyl](2,3-dihydro-1,4-benzodioxin-6-yl)amino]-N(un/substituted-phenyl)acetamides
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Nazir M.; Ali Shah S.A.; Shahid M.
Published: (2020)

Synthesis of novel N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{[5-(un/substituted-phenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as potent antibacterial agents
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2022)

Design, synthesis and computational studies of N-(substituted-phenyl)-4-(4-phenyl-1-piperazinyl)butanamides as potent anti-melanogenic and tyrosinase inhibitors
by: Raza H.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Hassan M.; Shah S.A.A.; Shahid M.; Hong H.; Seo S.-Y.
Published: (2020)

Novel Bi-heterocycles as potent inhibitors of Urease and less cytotoxic agents: 3-({5-((2-amino-1,3-thiazol-4-yl)methyl)-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(un/substituted-phenyl) propanamides
by: Abbasi M.A.; Ramzan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hassan M.; Shah S.A.A.; Ashraf M.; Shahid M.; Seo S.-Y.
Published: (2020)

Synthesis of some new N-substituted-N-(2,3-Dihydro-[1,4]benzodioxin-6-yl)-4-acetamidobenzenesulfonamides as valuable antibacterial agents
by: Abbasi M.A.; Tariq S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ahmad I.; Malik R.; Shah S.A.A.
Published: (2016)

Synthesis and structural analysis of persuasive antibacterial agents and enzyme inhibitors derived from 5-(1-(4-Tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol
by: Aziz-Ur-Rehman; Sattar A.; Abbasi M.A.; Siddiqui S.Z.; Raza M.A.; Ashraf M.; Nazir M.; Shah S.A.A.
Published: (2018)

Mild hyperthermia (39°C) attenuates berberine chloride cytotoxicity against osteosarcoma cells
by: Ali Nashiry M.; Al-Khateeb A.R.; Din A.M.; Salim N.; Ismail A.M.; Keong Y.S.; Froemming G.R.
Published: (2019)

Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights
by: Hassan M.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2018)

Cytotoxic and Antibacterial Properties of Resveratrol Oligomers from the Stem Bark of Dryobalanops rappa
by: Wibowo A.; Ahmat N.; Biau F.J.; Loh J.S.; Hamzah A.S.
Published: (2022)

Synthesis of some unique carbamate derivatives bearing 2-furoyl-1-piperazine as a valuable therapeutic agents
by: Abbasi M.A.; Hussain G.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Lodhi M.A.; Ali Khan F.; Ashraf M.; Qurat-Ul-Ain; Ahmad I.; Malik R.; Shahid M.; Mushtaq Z.
Published: (2017)

Synthesis, characterization, antibacterial, α-glucosidase inhibition and hemolytic studies on some new n-(2,3-Dimethylphenyl)benzenesulfonamide derivatives
by: Abbasi M.A.; Islam M.; Aziz-ur-Rehman; Rasool S.; Rubab K.; Hussain G.; Ahmad I.; Ashraf M.; Shahid M.; Shah S.A.A.
Published: (2016)

Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, Malaysia
by: Hazalin N.A.M.N.; Ramasamy K.; Lim S.M.; Wahab I.A.; Cole A.L.J.; Abdul Majeed A.B.
Published: (2009)

Multi-selective reaction of azinane bearing oxadiazoles and substituted haloalkanes catalyzed by alkali metal hydride to access anti-enzymatic agents
by: Umair M.; Aziz-ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Khan S.U.; Shah S.A.A.
Published: (2024)

Land suitability for potential jatropha plantation in Malaysia
by: Mokhtar E.S.; Akhir N.M.; Zaki N.A.M.; Muharam F.M.; Pradhan B.; Lay U.S.
Published: (2021)

The Suitability of Matterport for Building Parcel Dimension Survey
by: Hariffin N.A.B.; Razali M.H.B.; Luh L.C.; Sulaiman S.A.; Hashim M.B.M.
Published: (2023)

Synthesis of some new propanamide derivatives bearing 4-piperidinyl-1,3,4-oxadiazole, and their evaluation as promising anticancer agents
by: Aziz-Ur-Rehman; Ahtzaz N.; Abbasi M.A.; Siddiqui S.Z.; Saleem S.; Manzoor S.; Iqbal J.; Virk N.A.; Chohan T.A.; Shah S.A.A.
Published: (2018)

Zorabots: A suitable robot-mediated telerehabilitation interface
by: Rosly M.A.; Kamaruzaman D.; Zulkornain L.H.; Shamsuddin S.; Zahari N.I.; Yussof H.
Published: (2020)

Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity
by: Ahmed S.; Govender T.; Khan I.; ur Rehman N.; Ali W.; Shah S.M.H.; Khan S.; Hussain Z.; Ullah R.; Alsaid M.S.
Published: (2018)

Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
by: Muhammad A. Abbasi; Irshad M.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2020)

Corpus-informed prepositions: What to learn and what is suitable for learning
by: Roslim N.; Aziz A.; Abdullah M.H.T.; Nimehchisalem V.
Published: (2021)

Synthesis of Novel Bi-Heterocycles as Valuable Anti-Diabetic Agents: 2-({5-((2-Amino-1,3-Thiazol-4-yl)methyl)-1,3,4-Oxadiazol-2-yl}sulfanyl)-N-(Substituted)acetamides
by: Muhammad Athar Abbasi; Ramzan M.S.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Lodhi M.A.; Khan F.A.; Mirza B.
Published: (2020)

N-(5-Methyl-1,3-Thiazol-2-yl)-2-{[5-((Un)Substituted- Phenyl)1,3,4-Oxadiazol-2-yl]Sulfanyl}acetamides. Unique Biheterocycles as Promising Therapeutic Agents
by: Abbasi M.A.; Ramzan M.S.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Hassan M.; Seo S.-Y.; Ashraf M.; Mirza B.; Ismail H.
Published: (2018)

The optimization of CNT-PVA nanocomposite for mild steel coating: Effect of CNTs concentration on the corrosion rate of mild steel
by: Maryam M.; Ibrahim N.M.A.A.; Eswar K.A.; Guliling M.; Suhaimi M.H.F.; Khusaimi Z.; Abdullah S.; Rusop M.
Published: (2018)