Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4′-(1,4-phenylene) bis(pyrimidin-2-amine) derivatives

QR Code

Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4′-(1,4-phenylene) bis(pyrimidin-2-amine) derivatives

Background: Pyrimidine molecules attracted organic chemists very much due to their biological and chemotherapeutic importance. Their related fused heterocycles are of interest as potential bioactive molecules so, we have designed and prepared a new class of 4,4′-(1,4-phenylene)bis(pyrimidin-2-amine)...

Full description

Bibliographic Details
Published in:	Chemistry Central Journal
Main Author:	Kumar S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053688716&doi=10.1186%2fs13065-018-0440-3&partnerID=40&md5=6b739738c81a43b80f764f6bf978bb0b

Similar Items

Design, synthesis and therapeutic potential of some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues
by: Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2019)

Design, synthesis and biological potential of 5-(2-amino-6-(3/4-bromophenyl)pyrimidin-4-yl)benzene-1,3-diol scaffolds as promising antimicrobial and anticancer agents
by: Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Ali Shah S.A.
Published: (2019)

Diazenyl schiff bases: Synthesis, spectral analysis, antimicrobial studies and cytotoxic activity on human colorectal carcinoma cell line (HCT-116)
by: Kaur H.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Narasimhan B.
Published: (2020)

4-(4-Bromophenyl)-Thiazol-2-Amine derivatives: Synthesis, biological activity and molecular docking study with ADME profile
by: Sharma D.; Kumar S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.
Published: (2019)

6-Benzyl-3-(1,4-dioxaspiro-[4.5]decan-2-yl)-8,8-dimethyl-1-oxa-2, 6-diaza-spiro-[4.4]non-2-ene-7,9-dione
by: Bathich Y.; Shaameri Z.; Hamzah A.S.; Quah C.K.; Fun H.-K.
Published: (2009)

Bis-pyrimidine acetamides: Design, synthesis and biological evaluation
by: Kumar S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Narasimhan B.
Published: (2017)

Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents
by: Kumar S.; Kaushik A.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2019)

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives
by: Kumar S.; Singh J.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2018)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
by: Kumar S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Selvaraj M.; Narasimhan B.
Published: (2017)

4-Thiazolidinone derivatives: Synthesis, antimicrobial, anticancer evaluation and QSAR studies
by: Deep A.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mishra R.K.; Mani V.
Published: (2016)

Synthesis, antimicrobial and cytotoxic evaluation of 4-(1-aryl-5-halo-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2017)

Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents
by: Sharma D.; Kumar S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.
Published: (2019)

Inhibition of angiogenesis and metastasis in colorectal cancer cell lines through KRAS-associated signaling pathways by 2-methoxy-6-undecyl-1,4-benzoquinone
by: Abd Rahman N.I.; Tham C.L.; Abd Hamid R.
Published: (2024)

Synthesis, Bacterial biofilm inhibition and cytotoxicity of new N-Alkyl/aralkyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-nitrobenzenesulfonamides
by: Abbasi M.A.; Zeb A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Shahid M.; Fatima H.
Published: (2020)

Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
by: Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
Published: (2014)

N′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: Synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies
by: Kumar P.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; De Clercq E.
Published: (2013)

4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
by: Tanjung M.; Aldin M.F.; Arif N.N.; Saputri R.D.; Ahmat N.; Tjahjandarie T.S.
Published: (2024)

4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
by: Tanjung, et al.
Published: (2024)

CD24, CD44 and EpCAM enrich for tumour-initiating cells in a newly established patient-derived xenograft of nasopharyngeal carcinoma
by: Hoe S.L.L.; Tan L.P.; Abdul Aziz N.; Liew K.; Teow S.-Y.; Abdul Razak F.R.; Chin Y.M.; Mohamed Shahrehan N.A.; Chu T.L.; Mohd Kornain N.K.; Peh S.-C.; Koay C.E.; Lo K.-W.; Ahmad M.; Ng C.-C.; Khoo A.S.-B.
Published: (2017)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Clercq E.D.; Narasimhan B.
Published: (2014)

4-(1-Aryl-5-chloro-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides: Synthesis, antimicrobial, anticancer evaluation and QSAR studies
by: Kumar M.; Narasimhan B.; Kumar P.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2014)

Crystal structure of 2,2'-(((2,2-dimethylpropane-1,3-diyl)bis(azanylylidene))- bis(methanylylidene))bis(4-methoxyphenol)palladium(II)
by: Ahmad S.N.; Bahron H.; Tajuddin A.M.; Sukeri M.M.Y.
Published: (2017)

A green and efficient synthetic methodology towards the synthesis of 1-allyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives
by: Gill M.S.A.; Azzman N.; Hassan S.S.; Shah S.A.A.; Ahemad N.
Published: (2022)

Synthesis of some new N-substituted-N-(2,3-Dihydro-[1,4]benzodioxin-6-yl)-4-acetamidobenzenesulfonamides as valuable antibacterial agents
by: Abbasi M.A.; Tariq S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ahmad I.; Malik R.; Shah S.A.A.
Published: (2016)

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
by: Kumari M.; Tahlan S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Kakkar S.
Published: (2021)

Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
by: Muhammad A. Abbasi; Irshad M.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2020)

Synthesis of promising antibacterial and antifungal agents: 2-[[(4-Chlorophenyl)sulfonyl](2,3-dihydro-1,4-benzodioxin-6-yl)amino]-N(un/substituted-phenyl)acetamides
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Nazir M.; Ali Shah S.A.; Shahid M.
Published: (2020)

The study of chromium oxide loading on platinum chromium oxide zirconia catalyst for n-dodecane and 1,4-diisopropylbenzene hydrocracking
by: Annuar N.H.R.; Teh L.P.; Setiabudi H.D.; Aziz M.A.A.; Salam N.M.; Jalil A.A.
Published: (2020)

Impact of Choline Chloride/1,4-Butanediol Deep Eutectic Solvent on Tamarind Seed Polysaccharide-Based Polymer Electrolyte Films
by: Fauzee M.H.M.; Suddin N.F.A.; Zailani N.A.M.; Nazir K.; Ismail S.N.S.; Zaini N.A.M.; Yahya S.; Latif F.A.
Published: (2024)

Goniolanceolatins A-H, Cytotoxic Bis-styryllactones from Goniothalamus lanceolatus
by: Bihud N.V.; Rasol N.E.; Imran S.; Awang K.; Ahmad F.B.; Mai C.-W.; Leong C.-O.; Cordell G.A.; Ismail N.H.
Published: (2019)

2-mercaptobenzimidazole schiff bases: Design, synthesis, antimicrobial studies and anticancer activity on HCT-116 cell line
by: Tahlan S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2019)

Synthesis of new 2-{2,3-dihydro-1,4-benzodioxin-6-yl[(4‑methylphenyl) sulfonyl]amino}-N-(un/substituted-phenyl) acetamides as α-glucosidase and acetylcholinesterase inhibitors and their in silico study
by: Abbasi M.A.; Riaz S.; Aziz-Ur-rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Lodhi M.A.; Khan F.A.
Published: (2019)

4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2019)

Enhanced antimicrobial property of polyurethane fibers bearing nanoparticles of polyacrylic acid-grafted oleyl amine and zwitterion
by: Muhammad A.B.; Tian K.; Park J.
Published: (2024)

Enhanced antimicrobial property of polyurethane fibers bearing nanoparticles of polyacrylic acid-grafted oleyl amine and zwitterion
by: Muhammad, et al.
Published: (2024)

Synthesis of novel N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{[5-(un/substituted-phenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as potent antibacterial agents
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2022)

Acquired radioresistance in EMT6 mouse mammary carcinoma cell line is mediated by CTLA-4 and PD-1 through JAK/STAT/PI3K pathway
by: Sham N.F.R.; Hasani N.A.H.; Hasan N.; Karim M.K.A.; Fuad S.B.S.A.; Hasbullah H.H.; Ibahim M.J.
Published: (2023)

Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity
by: Abbasi M.A.; Nazeer M.M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Ahmad I.; Shahid M.; Sarwar M.S.
Published: (2018)

In vitro cytotoxic evaluation and apoptotic effects of dillapiole on human nasal squamous cell carcinoma
by: Ruslan N.B.; Amin I.M.; Hasani N.A.H.; Ahmad V.N.; Aris F.; Heah K.G.
Published: (2021)