IOP lowering effect of topical trans-resveratrol involves adenosine receptors and TGF-β2 signaling pathways

QR Code

IOP lowering effect of topical trans-resveratrol involves adenosine receptors and TGF-β2 signaling pathways

Trans-resveratrol was earlier shown to lower intraocular pressure (IOP) in rats; however, its mechanisms of action remain unclear. It has been shown to modulate adenosine receptor (AR) and TGF-β2 signaling, both of which play a role in regulating IOP. Hence, we investigated effects of trans-resverat...

Full description

Bibliographic Details
Published in:	European Journal of Pharmacology
Main Author:	Razali N.; Agarwal R.; Agarwal P.; Froemming G.R.A.; Tripathy M.; Ismail N.M.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053084998&doi=10.1016%2fj.ejphar.2018.08.035&partnerID=40&md5=e31c150790554dd9a9276323748c64be

Similar Items

Role of adenosine receptors in resveratrol-induced intraocular pressure lowering in rats with steroid-induced ocular hypertension
by: Razali N.; Agarwal R.; Agarwal P.; Kumar S.; Tripathy M.; Vasudevan S.; Crowston J.G.; Ismail N.M.
Published: (2015)

Neuroprotection by Trans-Resveratrol in Rats with Intracerebral Hemorrhage: Insights into the Role of Adenosine A1 Receptors
by: Abd. Aziz N.A.W.; Iezhitsa I.; Agarwal R.; Bakar N.S.; Abd. Latiff A.; Ismail N.M.
Published: (2022)

Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells
by: Bakar A.S.A.; Razali N.; Agarwal R.; Iezhitsa I.; Perfilev M.A.; Vassiliev P.M.
Published: (2024)

Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats
by: Nasir N.A.A.; Agarwal R.; Kadir S.H.S.A.; Vasudevan S.; Tripathy M.; Iezhitsa I.; Daher A.M.; Ibrahim M.I.; Ismail N.M.
Published: (2017)

Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats
by: Agarwal R.; Gupta S.K.; Agarwal P.; Srivastava S.
Published: (2013)

Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway
by: Zakaria Z.A.; Abdul Rahim M.H.; Mohd Sani M.H.; Omar M.H.; Ching S.M.; Abdul Kadir A.; Ahmed Q.U.
Published: (2019)

Osteoblast Demineralization Induced by Oxidized High-Density Lipoprotein via the Inflammatory Pathway Is Suppressed by Adiponectin
by: Harun N.H.; Froemming G.R.A.; Mohd Ismail A.; Nawawi H.; Mokhtar S.S.; Abd Muid S.
Published: (2022)

Osteoporosis: Possible pathways involved and the role of natural phytoestrogens in bone metabolism
by: Thent Z.C.; Das S.; Mahakkanukrauh P.; Lanzotti V.
Published: (2019)

Baeckea frutescens L. Promotes wound healing by upregulating expression of TGF-β, IL-1 β, VEGF and MMP-2
by: Safwan Kamarazaman I.; Sui Kiong L.; Nik Hasan M.K.; Basherudin N.; Mohd Kasim N.A.; Ali A.A.; Ramli S.; Maniam S.; Johari James R.; Rojsitthisak P.; Halim H.
Published: (2024)

Baeckea frutescens L. Promotes wound healing by upregulating expression of TGF-β, IL-1 β, VEGF and MMP-2
by: Kamarazaman, et al.
Published: (2024)

Mucoadhesive nanopolymer - A novel drug carrier for topical ocular drug delivery
by: Sahoo S.; Sahoo R.; Nanda R.; Tripathy M.K.; Nayak P.L.
Published: (2010)

Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering
by: Hassan M.D.S.; Razali N.; Abu Bakar A.S.; Abu Hanipah N.F.; Agarwal R.
Published: (2023)

Eurycomanone and eurycomanol from Eurycoma longifolia jack as regulators of signaling pathways involved in proliferation, cell death and inflammation
by: Hajjouli S.; Chateauvieux S.; Teiten M.-H.; Orlikova B.; Schumacher M.; Dicato M.; Choo C.-Y.; Diederich M.
Published: (2014)

Designing the Right Games Strategy: Evidence-Based Technology of Teaching Games for Understanding (TGfU) Model
by: Abdul Ghani D.Z.; Zainuddin Z.A.; Mohd Hashim A.H.; Ibrahim H.; Mohamed A.M.D.
Published: (2024)

Protective effect of magnesium acetyltaurate against NMDA-induced retinal damage involves restoration of minerals and trace elements homeostasis
by: Jafri A.J.A.; Arfuzir N.N.N.; Lambuk L.; Iezhitsa I.; Agarwal R.; Agarwal P.; Razali N.; Krasilnikova A.; Kharitonova M.; Demidov V.; Serebryansky E.; Skalny A.; Spasov A.; Yusof A.P.M.; Ismail N.M.
Published: (2017)

Resveratrol Oligomers from the Twigs of Neobalanocarpus heimii ( King) PS Ashton (Dipterocarpaceae)
by: Zakaria, et al.
Published: (2023)

Comparative Dose- and Time-Dependent Manner of Resveratrol on Human Epithelial Cell Types
by: Effendy W.N.F.W.E.; S. M. N. Mydin R.B.; Shanker K.; Ng K.Y.; Sundaraju P.; Gunasagaran S.; Ahmad Sopian S.F.; Mohd Gazzali A.
Published: (2022)

Cytotoxic and Antibacterial Properties of Resveratrol Oligomers from the Stem Bark of Dryobalanops rappa
by: Wibowo A.; Ahmat N.; Biau F.J.; Loh J.S.; Hamzah A.S.
Published: (2022)

A scoping review of topic modelling on online data
by: Sharif M.M.M.; Maskat R.; Baharum Z.; Maskat K.
Published: (2023)

Intraocular pressure-lowering effects of imidazo[1,2-a]- and pyrimido[1,2-a]benzimidazole compounds in rats with dexamethasone-induced ocular hypertension
by: Marcus A.J.; Iezhitsa I.; Agarwal R.; Vassiliev P.; Spasov A.; Zhukovskaya O.; Anisimova V.; Ismail N.M.
Published: (2019)

Chemotaxonomic Relationship of Oligomer Resveratrol in Three Malaysian Dipterocarpus Species from the Taxonomic Tribe of Dipterocarpaceae
by: Nawi L.; Zain W.Z.W.M.; Ahmat N.; Osman C.P.; Takaya Y.; Kamarozaman A.S.; Adnan N.; Azahar S.Z.
Published: (2024)

Understanding Text Messages for Anxiety Therapy Through Topic Modeling
by: Rahman T.F.A.; Nayan N.M.
Published: (2024)

A Survey on Topics Rating for the Undergraduate and Diploma in Environmental Health
by: Arshad K.; Lean Q.Y.; Ming L.C.; Mahalingam S.R.; Tiong C.S.; Abdullah A.H.; Shafie F.A.
Published: (2018)

Phytoestrogens by inhibiting the non-classical oestrogen receptor, overcome the adverse effect of bisphenol A on hFOB 1.19 cells
by: Thent Z.C.; Ruth Anisah Froemming G.; Binti Mohd Ismail A.; Baharom Syed Ahmad Fuad S.; Muid S.
Published: (2020)

Regio- and stereoselective biomimetic synthesis of oligostilbenoid dimers from resveratrol analogues: Influence of the solvent, oxidant, and substitution
by: Velu S.S.; Buniyamin I.; Ching L.K.; Feroz F.; Noorbatcha I.; Gee L.C.; Awang K.; Wahab I.Abd.; Weber J.-F.F.
Published: (2008)

ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats
by: Ibrahim H.S.; Froemming G.R.A.; Omar E.; Singh H.J.
Published: (2014)

Tocotrienol preserves ovarian function in cyclophosphamide therapy
by: Saleh H.S.; Omar E.; Froemming G.R.A.; Said R.M.
Published: (2015)

Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
by: Ibrahim H.S.; Omar E.; Froemming G.R.A.; Singh H.J.
Published: (2013)

Synthesis of Trans-4-Hydroxyprolineamide and 3-Ketoproline Ethyl Ester for Green Asymmetric Organocatalysts
by: Abdullah N.; Shaameri Z.; Hamzah A.S.; Mohammat M.F.
Published: (2024)

Inhibition of miR-96-5p alleviates intervertebral disc degeneration by regulating the peroxisome proliferator-activated receptor γ/nuclear factor-kappaB pathway
by: Li X.; Hou Q.; Yuan W.; Zhan X.; Yuan H.
Published: (2023)

Cobalt containing glass fibres and their synergistic effect on the HIF-1 pathway for wound healing applications
by: Solanki A.K.; Autefage H.; Rodriguez A.R.; Agarwal S.; Penide J.; Mahat M.; Whittaker T.; Nommeots-Nomm A.; Littmann E.; Payne D.J.; Metcalfe A.D.; Quintero F.; Pou J.; Stevens M.M.; Jones J.R.
Published: (2023)

Development of N-alkylated benzimidazole based cubosome hydrogel for topical treatment of burns
by: Nawaz M.; Hayat S.; Farooq U.; Iqbal M.A.; Khalid S.H.; Nee T.W.; Khaw K.Y.; Munir R.; Ijaz M.U.
Published: (2024)

Mapping the Demand for Ecosystem Services in Human-Dominated Topical Forest of Sabah, Malaysia
by: Kamlun K.U.; Bürger-Arndt R.; Fatah F.A.
Published: (2024)

Development of N-alkylated benzimidazole based cubosome hydrogel for topical treatment of burns
by: Nawaz, et al.
Published: (2024)

Trans-Pacific Partnership Agreement and Its Impact on Accessibility and Affordability of Medicines: A Meta-synthesis
by: Yap Y.Y.; Wong C.P.; Lee K.S.; Ming L.C.; Khan T.M.
Published: (2017)

Intraocular pressure lowering effect and structure-activity relationship of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats: Insight on possible link with hypotensive activity
by: Marcus A.J.; Iezhitsa I.; Agarwal R.; Vassiliev P.; Spasov A.; Zhukovskaya O.; Anisimova V.; Johari B.; Mohd Ismail N.
Published: (2018)

Screening of differential promoter hypermethylated genes in primary oral squamous cell carcinoma
by: Khor G.H.; Froemming G.R.A.; Zain R.B.; Abraham M.T.; Thong K.L.
Published: (2014)

Effect of different solvents on nisin ZP potential as anticancer agent against MG-63 osteosarcoma cells
by: Azmi M.F.; Al Khateeb A.; Rahim S.A.; Froemming G.R.A.; Omar E.
Published: (2022)

Governance of research involving people with psychosocial disabilities
by: Wickremsinhe M.; Carrecedo S.; Yakubu A.; Yusof A.N.M.; Kaur S.
Published: (2023)

Anti-inflammatory effects of high-density lipoprotein via regulation of nitric oxide synthase expression and Nf-κb transcription in activated human endothelial cells
by: Wan Yusoff W.N.; Chua Y.-A.; Froemming G.R.A.; Ali A.M.; Nawawi H.
Published: (2017)