3-Benzyl(phenethyl)-2-thioxobenzo[g]quinazolines as a new class of potent α-glucosidase inhibitors: Synthesis and molecular docking study

QR Code

3-Benzyl(phenethyl)-2-thioxobenzo[g]quinazolines as a new class of potent α-glucosidase inhibitors: Synthesis and molecular docking study

Aim: Using a simple modification on a previously reported synthetic route, 3-benzyl(phenethyl)-2-thioxobenzo[g]quinazolin-4(3H)-ones (1 and 2) were synthesized with high yields. Further transformation of 1 and 2 produced derivatives 3-26, which were structurally characte...

Full description

Bibliographic Details
Published in:	Future Medicinal Chemistry
Main Author:	Al-Salahi R.; Ahmad R.; Anouar E.; Iwana Nor Azman N.I.; Marzouk M.; Abuelizz H.A.
Format:	Article
Language:	English
Published:	Future Medicine Ltd. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051851796&doi=10.4155%2ffmc-2018-0141&partnerID=40&md5=b8383e3ff482a4404b33b01fafc6d37b

Similar Items

Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors
by: Abuelizz H.A.; Iwana N.A.N.I.; Ahmad R.; Anouar E.-H.; Marzouk M.; Al-Salahi R.
Published: (2019)

Evaluation of cytotoxic and tyrosinase inhibitory activities of 2-phenoxy(Thiomethyl) pyridotriazolopyrimidines: In vitro and molecular docking studies
by: Abuelizz H.A.; Anouar E.H.; Marzouk M.; Hasan M.H.; Saleh S.R.; Ahudhaif A.; Alburikan K.A.; Al-Salahi R.
Published: (2020)

Evaluation of 2-indolcarbohydrazones as potent α-glucosidase inhibitors, in silico studies and DFT based stereochemical predictions
by: Taha M.; Ismail N.H.; Javaid K.; Imran S.; Anouar E.H.; Wadood A.; Atia-Tul-Wahab; Ali M.; Khan K.M.; Saad S.M.; Rahim F.; Choudhary M.I.
Published: (2015)

Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton
by: Khan K.M.; Rahim F.; Wadood A.; Kosar N.; Taha M.; Lalani S.; Khan A.; Fakhri M.I.; Junaid M.; Rehman W.; Khan M.; Perveen S.; Sajid M.; Choudhary M.I.
Published: (2014)

Synthesis of Bis-indolylmethane sulfonohydrazides derivatives as potent α-Glucosidase inhibitors
by: Gollapalli M.; Taha M.; Ullah H.; Nawaz M.; AlMuqarrabun L.M.R.; Rahim F.; Qureshi F.; Mosaddik A.; Ahmat N.; Khan K.M.
Published: (2018)

Triazinoindole analogs as potent inhibitors of α-glucosidase: Synthesis, biological evaluation and molecular docking studies
by: Rahim F.; Ullah K.; Ullah H.; Wadood A.; Taha M.; Rehman A.U.; Uddin I.; Ashraf M.; Shaukat A.; Rehman W.; Hussain S.; Khan K.M.
Published: (2015)

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study
by: Ullah H.; Khan S.; Rahim F.; Taha M.; Iqbal R.; Sarfraz M.; Shah S.A.A.; Sajid M.; Awad M.F.; Omran A.; Albalawi M.A.; Abdelaziz M.A.; Al Areefy A.; Jafri I.
Published: (2022)

Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes
by: Ullah W.; Rahim F.; Hayat S.; Ullah H.; Taha M.; Khan S.; Khaliq A.; Bibi S.; Gohar O.; Iqbal N.; Shah S.A.A.; Khan K.M.
Published: (2024)

Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Ali M.; Rehman A.U.
Published: (2015)

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats
by: Taha M.; Imran S.; Salahuddin M.; Iqbal N.; Rahim F.; Uddin N.; Shehzad A.; Khalid Farooq R.; Alomari M.; Mohammed Khan K.
Published: (2021)

New benzoxazole-based sulphonamide hybrids analogs as potent inhibitors of α-amylase and α-glucosidase: Synthesis and in vitro evaluation along with in silico study
by: Khan S.; Rahim F.; Rehman W.; Nawaz M.; Taha M.; Fazil S.; Hussain R.; Adnan Ali Shah S.; Abdellatif M.H.
Published: (2022)

New biologically dynamic hybrid pharmacophore triazinoindole-based-thiadiazole as potent α-glucosidase inhibitors: In vitro and in silico study
by: Khan A.A.; Rahim F.; Taha M.; Rehman W.; Iqbal N.; Wadood A.; Ahmad N.; Shah S.A.A.; Ghoneim M.M.; Alshehri S.; Salahuddin M.; Khan K.M.
Published: (2022)

Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights
by: Ur Rahman S.; Alam A.; Parveen Z.; Zainab; Assad M.; Adnan Ali Shah S.; Rafiq H.; Ayaz M.; Latif A.; Naveed Umar M.; Ali M.; Ahmad M.
Published: (2024)

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023)

Synthesis, molecular docking studies of hybrid benzimidazole as α-glucosidase inhibitor
by: Zawawi N.K.N.A.; Taha M.; Ahmat N.; Ismail N.H.; Wadood A.; Rahim F.
Published: (2017)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
by: Taha M.; Shah S.A.A.; Afifi M.; Imran S.; Sultan S.; Rahim F.; Khan K.M.
Published: (2018)

Biscoumarin analogs: Synthesis, α-glucosidase inhibitory potential and molecular docking study
by: Ahmat N.; Nik Abdullah Zawawi N.K.; Taha M.; Wadood A.; Rahim F.; Ullah H.
Published: (2020)

Synthesis, in vitro and Docking Studies of New Flavone Ethers as α-Glucosidase Inhibitors
by: Imran S.; Taha M.; Ismail N.H.; Kashif S.M.; Rahim F.; Jamil W.; Wahab H.; Khan K.M.
Published: (2016)

Synthesis of new oxadiazole derivatives as α-glucosidase inhibitors
by: Taha M.; Ismail N.H.; Imran S.; Rokei M.Q.B.; Saad S.M.; Khan K.M.
Published: (2015)

α-Glucosidase inhibition of lactone intermediates of the iminosugar deoxynojirimycin
by: Haan Y.W.; Al-Bajalan H.M.; Sage E.E.; Elangovan D.; Yajit N.L.M.; Sarizan N.M.; Zitzmann N.; Kiappes J.L.; Hasbullah S.A.; Ismail N.H.; Mackeen M.M.
Published: (2019)

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs
by: Javid M.T.; Rahim F.; Taha M.; Rehman H.U.; Nawaz M.; wadood A.; Imran S.; Uddin I.; Mosaddik A.; Khan K.M.
Published: (2018)

Synthesis, α-glucosidase inhibitory, cytotoxicity and docking studies of 2-aryl-7-methylbenzimidazoles
by: Taha M.; Ismail N.H.; Imran S.; Mohamad M.H.; Wadood A.; Rahim F.; Saad S.M.; Rehman A.U.; Khan K.M.
Published: (2016)

Synthesis, in vitro α-glucosidase activity and in silico molecular docking study of isatin analogues
by: Ullah H.; Rahim F.; Ullah E.; Hayat S.; Zada H.; Khan F.; Wadood A.; Nawaz F.; Rehman Z.U.; Shah S.A.A.
Published: (2023)

New thiazole-based thiazolidinone derivatives: Synthesis, in vitro α-amylase, α-glucosidase activities and silico molecular docking study
by: Khan S.; Ullah H.; Rahim F.; Taha M.; Hussain R.; Khan M.S.; Ali H.; Khan M.U.; Shah S.A.A.; Khan K.M.
Published: (2022)

α-Glucosidase inhibition and docking studies of 5-deoxyflavonols and dihydroflavonols isolated from abutilon Pakistanicum
by: Hussain M.; Ahmed Z.; Khan S.N.; Shah S.A.A.; Razi R.; Imran S.; Khalid M.; Ali B.; Irshad M.B.; Nawaz F.; Chaudhry M.I.
Published: (2019)

Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase
by: Rahim F.; Ullah H.; Javid M.T.; Wadood A.; Taha M.; Ashraf M.; Shaukat A.; Junaid M.; Hussain S.; Rehman W.; Mehmood R.; Sajid M.; Khan M.N.; Khan K.M.
Published: (2015)

Isatin based thiosemicarbazide derivatives as potential inhibitor of α-glucosidase, synthesis and their molecular docking study
by: Rahim F.; Taha M.; Iqbal N.; Hayat S.; Qureshi F.; Uddin I.; Zaman K.; Rab A.; Wadood A.; Uddin N.; Nawaz M.; Shah S.A.A.; Khan K.M.
Published: (2020)

Synthesis of Novel Soritin Sulfonamide Derivatives as Potential α-Glucosidase Inhibitor and Their Molecular Docking Studies
by: Inayatsyah, et al.
Published: (2024)

Synthesis of Novel Soritin Sulfonamide Derivatives as Potential α-Glucosidase Inhibitor and Their Molecular Docking Studies
by: Inayatsyah N.; Ridhwan M.; Aznirulhisham A.; Rasol N.; Kasim N.; Imran S.
Published: (2024)

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
by: Khan K.M.; Qurban S.; Salar U.; Taha M.; Hussain S.; Perveen S.; Hameed A.; Ismail N.H.; Riaz M.; Wadood A.
Published: (2016)

Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies
by: Zawawi N.K.N.A.; Taha M.; Ahmat N.; Wadood A.; Ismail N.H.; Rahim F.; Azam S.S.; Abdullah N.
Published: (2016)

Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of α-glucosidases
by: Zawawi N.K.N.A.; Taha M.; Ahmat N.; Ismail N.H.; Wadood A.; Rahim F.; Rehman A.U.
Published: (2015)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
by: Taha M.; Alshamrani F.J.; Rahim F.; Hayat S.; Ullah H.; Zaman K.; Imran S.; Khan K.M.; Naz F.
Published: (2019)

Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies
by: Imran S.; Taha M.; Ismail N.H.; Kashif S.M.; Rahim F.; Jamil W.; Hariono M.; Yusuf M.; Wahab H.
Published: (2015)

Oxindole based oxadiazole hybrid analogs: Novel α-glucosidase inhibitors
by: Taha M.; Imran S.; Rahim F.; Wadood A.; Khan K.M.
Published: (2018)

Antioxidant and α-glucosidase inhibitory constituents from Hornstedtia species of Malaysia
by: Hashim S.E.; Sirat H.M.; Yen K.H.; Ismail I.S.; Matsuki S.N.
Published: (2015)

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes
by: Hussain S.; Taha M.; Rahim F.; Hayat S.; Zaman K.; Iqbal N.; Selvaraj M.; Sajid M.; Bangesh M.A.; Khan F.; Khan K.M.; Uddin N.; Shah S.A.A.; Ali M.
Published: (2021)

Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors
by: Arshad T.; Khan K.M.; Rasool N.; Salar U.; Hussain S.; Tahir T.; Ashraf M.; Wadood A.; Riaz M.; Perveen S.; Taha M.; Ismail N.H.
Published: (2016)

Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies
by: Taha M.; Ismail N.H.; Lalani S.; Fatmi M.Q.; Atia-Tul-Wahab; Siddiqui S.; Khan K.M.; Imran S.; Choudhary M.I.
Published: (2015)

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
by: Rahim F.; Malik F.; Ullah H.; Wadood A.; Khan F.; Javid M.T.; Taha M.; Rehman W.; Ur Rehman A.; Khan K.M.
Published: (2015)