Cocrystal Screening of Ibuprofen with Oxalic Acid and Citric Acid via Grinding Method

• Published in: IOP Conference Series: Materials Science and Engineering
• Main Author: Othman M.F.; Anuar N.; Ad Rahman S.; Ahmad Taifuddin N.A.
• Format: Conference paper
• Language: English
• Published: Institute of Physics Publishing 2018
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050612255&doi=10.1088%2f1757-899X%2f358%2f1%2f012065&partnerID=40&md5=27e77079bf22d1bb451b47b46b0953ca

Ibuprofen is a Class II Biological Safety Class (BSC) drugs used for relief of arthritis, as an analgesic and possesses the effect of antiplatelet. The major problem involves in ibuprofen is it has a low solubility and high permeability thus causes an unsatisfactory therapeutic effect to humans. Thus, in this work, alteration of ibuprofen's physicochemical properties is conducted by means of cocrystallization technique. Co-crystallizations of ibuprofen were prepared with selected coformers using dry grinding and liquid assisted grinding (LAG) techniques in different molar ratios while ethanol and propanol were used as a solvent. The new crystalline forms were identified and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and fourier transform infrared spectroscopy (FTIR). Analysis for Ibuprofen-Citric acid (IBP-CA) system, co-crystal was successfully formed in 1:2, 1:3, 2:1 and 3:1 molar ratios for neat grinding method although the co-crystal produced is unstable. Meanwhile, for Ibuprofen-Oxalic acid (IBP-OA) system, the co-crystal formation was identified only in 1:1, 1:2 and 1:3 molar ratios for the neat grinding method. LAG method shows that co-crystal formation was unsuccessful in both solvents for IBP-CA, while IBP-OA co-crystal was formed in the molar ratio 1:1, 2:1 and 3:1 in ethanol, and 2:1 and 3:1 in propanol. © Published under licence by IOP Publishing Ltd.