Synthesis, SAR elucidations and molecular docking study of newly designed isatin based oxadiazole analogs as potent inhibitors of thymidine phosphorylase

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Synthesis, SAR elucidations and molecular docking study of newly designed isatin based oxadiazole analogs as potent inhibitors of thymidine phosphorylase

Thymidine phosphorylase is an enzyme involved in pyrimidine salvage pathway that is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and gliostatin. It is enormously up regulated in a variety of solid tumors. Furthermore, surpassing of TP level prot...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Javid M.T.; Rahim F.; Taha M.; Nawaz M.; Wadood A.; Ali M.; Mosaddik A.; Shah S.A.A.; Farooq R.K.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047345848&doi=10.1016%2fj.bioorg.2018.05.011&partnerID=40&md5=1382efb7b09ea9d905d04f2b7d6cf11a

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