Data on the effects of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on intraocular pressure of ocular normotensive rats

• Published in: Data in Brief
• Main Author: Marcus A.J.; Iezhitsa I.; Agarwal R.; Vassiliev P.; Spasov A.; Zhukovskaya O.; Anisimova V.; Mohd Ismail N.
• Format: Data paper
• Language: English
• Published: Elsevier Inc. 2018
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044521640&doi=10.1016%2fj.dib.2018.03.019&partnerID=40&md5=9e11e7e1387f8f1e11245d2583ad57c1

This data is to document the intraocular pressure (IOP) lowering activity of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats. Effects of single drop application of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on IOP in ocular normotensive rats are presented at 3 different concentrations (0.1%, 0.2% and 0.4%). Time course of changes in IOP is presented over 6 h period post-instillation. The IOP lowering activities of test compounds were determined by assessing maximum decrease in IOP from baseline and corresponding control, duration of IOP lowering and area under curve (AUC) of time versus response curve. Data shown here may serve as benchmarks for other researchers studying IOP-lowering effect of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds and would be useful in determining therapeutic potential of these test compounds as IOP lowering agents. © 2018 The Authors