Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives

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Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives

We have synthesized oxadiazole derivatives (1–16), characterized by 1H NMR, 13C NMR and HREI-MS and screened for thymidine phosphorylase inhibitory potential. All derivatives display varied degree of thymidine phosphorylase inhibition in the range of 1.10 ± 0.05 to 49.60 ± 1.30 μM when compared with...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Ullah H.; Rahim F.; Taha M.; Uddin I.; Wadood A.; Shah S.A.A.; Farooq R.K.; Nawaz M.; Wahab Z.; Khan K.M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043523886&doi=10.1016%2fj.bioorg.2018.02.020&partnerID=40&md5=deb0fe7a6b48ad3f0a96201fc44143e2

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