Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives

Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives

We have synthesized oxadiazole derivatives (1–16), characterized by 1H NMR, 13C NMR and HREI-MS and screened for thymidine phosphorylase inhibitory potential. All derivatives display varied degree of thymidine phosphorylase inhibition in the range of 1.10 ± 0.05 to 49.60 ± 1.30 μM when compared with...

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Bibliographic Details
Published in:Bioorganic Chemistry
Main Author: Ullah H.; Rahim F.; Taha M.; Uddin I.; Wadood A.; Shah S.A.A.; Farooq R.K.; Nawaz M.; Wahab Z.; Khan K.M.
Format: Article
Language:English
Published: Academic Press Inc. 2018
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043523886&doi=10.1016%2fj.bioorg.2018.02.020&partnerID=40&md5=deb0fe7a6b48ad3f0a96201fc44143e2

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043523886&doi=10.1016%2fj.bioorg.2018.02.020&partnerID=40&md5=deb0fe7a6b48ad3f0a96201fc44143e2

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