Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data

Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data

The region of northern Borneo is home to the current state of Sabah, Malaysia. It is located closest to the southern Philippine islands and may have served as a viaduct for ancient human migration onto or off of Borneo Island. In this study, five indigenous ethnic groups from Sabah were subjected to...

Full description

Bibliographic Details
Published in:Annals of Human Genetics
Main Author: Yew C.W.; Hoque M.Z.; Pugh-Kitingan J.; Minsong A.; Voo C.L.Y.; Ransangan J.; Lau S.T.Y.; Wang X.; Saw W.Y.; Ong R.T.-H.; Teo Y.-Y.; Xu S.; Hoh B.-P.; Phipps M.E.; Kumar S.V.
Format: Article
Language:English
Published: Blackwell Publishing Ltd 2018
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043394169&doi=10.1111%2fahg.12246&partnerID=40&md5=ecab7793ff6f52bc55123a7ef1c5ade5
id 2-s2.0-85043394169
spelling 2-s2.0-85043394169
Yew C.W.; Hoque M.Z.; Pugh-Kitingan J.; Minsong A.; Voo C.L.Y.; Ransangan J.; Lau S.T.Y.; Wang X.; Saw W.Y.; Ong R.T.-H.; Teo Y.-Y.; Xu S.; Hoh B.-P.; Phipps M.E.; Kumar S.V.
Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data
2018
Annals of Human Genetics
82
4
10.1111/ahg.12246
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043394169&doi=10.1111%2fahg.12246&partnerID=40&md5=ecab7793ff6f52bc55123a7ef1c5ade5
The region of northern Borneo is home to the current state of Sabah, Malaysia. It is located closest to the southern Philippine islands and may have served as a viaduct for ancient human migration onto or off of Borneo Island. In this study, five indigenous ethnic groups from Sabah were subjected to genome-wide SNP genotyping. These individuals represent the “North Borneo”-speaking group of the great Austronesian family. They have traditionally resided in the inland region of Sabah. The dataset was merged with public datasets, and the genetic relatedness of these groups to neighboring populations from the islands of Southeast Asia, mainland Southeast Asia and southern China was inferred. Genetic structure analysis revealed that these groups formed a genetic cluster that was independent of the clusters of neighboring populations. Additionally, these groups exhibited near-absolute proportions of a genetic component that is also common among Austronesians from Taiwan and the Philippines. They showed no genetic admixture with Austro-Melanesian populations. Furthermore, phylogenetic analysis showed that they are closely related to non–Austro-Melansian Filipinos as well as to Taiwan natives but are distantly related to populations from mainland Southeast Asia. Relatively lower heterozygosity and higher pairwise genetic differentiation index (FST) values than those of nearby populations indicate that these groups might have experienced genetic drift in the past, resulting in their differentiation from other Austronesians. Subsequent formal testing suggested that these populations have received no gene flow from neighboring populations. Taken together, these results imply that the indigenous ethnic groups of northern Borneo shared a common ancestor with Taiwan natives and non–Austro-Melanesian Filipinos and then isolated themselves on the inland of Sabah. This isolation presumably led to no admixture with other populations, and these individuals therefore underwent strong genetic differentiation. This report contributes to addressing the paucity of genetic data on representatives from this strategic region of ancient human migration event(s). © 2018 John Wiley & Sons Ltd/University College London
Blackwell Publishing Ltd
34800
English
Article
author Yew C.W.; Hoque M.Z.; Pugh-Kitingan J.; Minsong A.; Voo C.L.Y.; Ransangan J.; Lau S.T.Y.; Wang X.; Saw W.Y.; Ong R.T.-H.; Teo Y.-Y.; Xu S.; Hoh B.-P.; Phipps M.E.; Kumar S.V.
spellingShingle Yew C.W.; Hoque M.Z.; Pugh-Kitingan J.; Minsong A.; Voo C.L.Y.; Ransangan J.; Lau S.T.Y.; Wang X.; Saw W.Y.; Ong R.T.-H.; Teo Y.-Y.; Xu S.; Hoh B.-P.; Phipps M.E.; Kumar S.V.
Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data
author_facet Yew C.W.; Hoque M.Z.; Pugh-Kitingan J.; Minsong A.; Voo C.L.Y.; Ransangan J.; Lau S.T.Y.; Wang X.; Saw W.Y.; Ong R.T.-H.; Teo Y.-Y.; Xu S.; Hoh B.-P.; Phipps M.E.; Kumar S.V.
author_sort Yew C.W.; Hoque M.Z.; Pugh-Kitingan J.; Minsong A.; Voo C.L.Y.; Ransangan J.; Lau S.T.Y.; Wang X.; Saw W.Y.; Ong R.T.-H.; Teo Y.-Y.; Xu S.; Hoh B.-P.; Phipps M.E.; Kumar S.V.
title Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data
title_short Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data
title_full Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data
title_fullStr Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data
title_full_unstemmed Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data
title_sort Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data
publishDate 2018
container_title Annals of Human Genetics
container_volume 82
container_issue 4
doi_str_mv 10.1111/ahg.12246
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043394169&doi=10.1111%2fahg.12246&partnerID=40&md5=ecab7793ff6f52bc55123a7ef1c5ade5
description The region of northern Borneo is home to the current state of Sabah, Malaysia. It is located closest to the southern Philippine islands and may have served as a viaduct for ancient human migration onto or off of Borneo Island. In this study, five indigenous ethnic groups from Sabah were subjected to genome-wide SNP genotyping. These individuals represent the “North Borneo”-speaking group of the great Austronesian family. They have traditionally resided in the inland region of Sabah. The dataset was merged with public datasets, and the genetic relatedness of these groups to neighboring populations from the islands of Southeast Asia, mainland Southeast Asia and southern China was inferred. Genetic structure analysis revealed that these groups formed a genetic cluster that was independent of the clusters of neighboring populations. Additionally, these groups exhibited near-absolute proportions of a genetic component that is also common among Austronesians from Taiwan and the Philippines. They showed no genetic admixture with Austro-Melanesian populations. Furthermore, phylogenetic analysis showed that they are closely related to non–Austro-Melansian Filipinos as well as to Taiwan natives but are distantly related to populations from mainland Southeast Asia. Relatively lower heterozygosity and higher pairwise genetic differentiation index (FST) values than those of nearby populations indicate that these groups might have experienced genetic drift in the past, resulting in their differentiation from other Austronesians. Subsequent formal testing suggested that these populations have received no gene flow from neighboring populations. Taken together, these results imply that the indigenous ethnic groups of northern Borneo shared a common ancestor with Taiwan natives and non–Austro-Melanesian Filipinos and then isolated themselves on the inland of Sabah. This isolation presumably led to no admixture with other populations, and these individuals therefore underwent strong genetic differentiation. This report contributes to addressing the paucity of genetic data on representatives from this strategic region of ancient human migration event(s). © 2018 John Wiley & Sons Ltd/University College London
publisher Blackwell Publishing Ltd
issn 34800
language English
format Article
accesstype
record_format scopus
collection Scopus
_version_ 1809678160203087872

Similar Items