A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity

A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity

The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were e...

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Published in:Natural Product Research
Main Author: Alhassan A.M.; Ahmed Q.U.; Latip J.; Shah S.A.A.
Format: Article
Language:English
Published: Taylor and Francis Ltd. 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041518915&doi=10.1080%2f14786419.2018.1437427&partnerID=40&md5=317eeff1032e52981459bebf37206308
id 2-s2.0-85041518915
spelling 2-s2.0-85041518915
Alhassan A.M.; Ahmed Q.U.; Latip J.; Shah S.A.A.
A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
2019
Natural Product Research
33
1
10.1080/14786419.2018.1437427
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041518915&doi=10.1080%2f14786419.2018.1437427&partnerID=40&md5=317eeff1032e52981459bebf37206308
The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Taylor and Francis Ltd.
14786419
English
Article
All Open Access; Green Open Access
author Alhassan A.M.; Ahmed Q.U.; Latip J.; Shah S.A.A.
spellingShingle Alhassan A.M.; Ahmed Q.U.; Latip J.; Shah S.A.A.
A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
author_facet Alhassan A.M.; Ahmed Q.U.; Latip J.; Shah S.A.A.
author_sort Alhassan A.M.; Ahmed Q.U.; Latip J.; Shah S.A.A.
title A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_short A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_full A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_fullStr A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_full_unstemmed A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_sort A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
publishDate 2019
container_title Natural Product Research
container_volume 33
container_issue 1
doi_str_mv 10.1080/14786419.2018.1437427
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041518915&doi=10.1080%2f14786419.2018.1437427&partnerID=40&md5=317eeff1032e52981459bebf37206308
description The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
publisher Taylor and Francis Ltd.
issn 14786419
language English
format Article
accesstype All Open Access; Green Open Access
record_format scopus
collection Scopus
_version_ 1792585532656582656

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