Secondary metabolites from endemic species Iris adriatica Trinajstić ex Mitić (Iridaceae)

• Published in: Natural Product Research
• Main Author: Bukvički D.; Novaković M.; Ab Ghani N.; Marin P.D.; Asakawa Y.
• Format: Article
• Language: English
• Published: Taylor and Francis Ltd. 2018
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033696429&doi=10.1080%2f14786419.2017.1402309&partnerID=40&md5=f15799df73615c99147ac654ed222422

This manuscript describes the first detailed chemical investigation of endemic species Iris adriatica, including isolation and structure elucidation. Chemical analyses of the rhizome CH2Cl2/MeOH (2:1) extract revealed fourteen secondary metabolites, mainly isoflavonoids. Among isoflavonoids, two groups have been found: nigricin-type and tectorigenin-type. Dominant group of the isolated compounds has been nigricin-type isoflavones: nigricin, nigricin-4′-(1-O-β-D-glucopyranoside) and nigricin-4′-(1-O-β-D-glucopyranosyl (1–6)-β-D-glucopyranoside) with 2.5, 10 and 1% of the total extract, respectively. Irisxanthone–xanthone C-glucoside, β-sitosterol, benzophenone and one of its derivatives have also been found. Nigricin-type isoflavonoids and irisxanthone can be considered as possible chemotaxonomic markers for I. adriatica. 5,3′,5′-Trimethoxy-6,7-methylenedioxyisoflavone-4′-(1-O-β-D-glucopyranoside) and benzophenone have been isolated from Iris species for the first time. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.