Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N′-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides

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Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N′-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides

Three series of 4-hydroxy-N′-[benzylidene/1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides (9–11)a-l were synthesized and unraveled to be highly potent dual inhibitors of monoamine oxidases (MAO-A and MAO-B). All the examined compounds demonstrated IC50 values in...

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Bibliographic Details
Published in:	European Journal of Medicinal Chemistry
Main Author:	Saddique F.A.; Zaib S.; Jalil S.; Aslam S.; Ahmad M.; Sultan S.; Naz H.; Iqbal M.; Iqbal J.
Format:	Article
Language:	English
Published:	Elsevier Masson s.r.l. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032899006&doi=10.1016%2fj.ejmech.2017.10.036&partnerID=40&md5=3910ef9cb034e3be2e6b7fbde44e28c9

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