Iron(II) complex of anthraquinone: Synthesis, structural elucidation and antimicrobial activity; [Komplek ferum(II) antrakuinon: Sintesis, penentuan struktur organik dan aktiviti antimikrob]

• Published in: Malaysian Journal of Analytical Sciences
• Main Author: Zaidel N.D.; Mian V.J.Y.; Mohamadin M.I.
• Format: Article
• Language: English
• Published: Malaysian Society of Analytical Sciences 2017
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032008494&doi=10.17576%2fmjas-2017-2105-20&partnerID=40&md5=02d4bd83b2bdc52dc6207c1b57ef465d

Our continuing interest in anthraquinone had led the researchers to look at the synthesis of metal complex by reacting our major compound, nordamnacanthal with transition metal, Fe(II). Fe(II)-nordamnacanthal complex had been synthesized successfully via telescoping synthesis/one-pot reaction. The ligand and its metal complex were established by 1D and 2D nuclear magnetic resonance spectroscopy, UV-Visible, CHNS analyzer, gas chromatography mass spectrometry and infrared analysis. They were evaluated for their antimicrobial activity using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Fe(II)-nordamnacanthal complex showed stronger inhibition against Pseudomonas aeruginosa at the concentration of 450 µg/mL while Proteus vulgaris, Klebsiella pneumoniae and Salmonella pneumoniae at the concentration of 225 µg/mL compare to nordamnacanthal. In this work, the synthesized compound, Fe(II)-nordamnacanthal showed better antimicrobial activity compared to the ligand itself. © 2017, Malaysian Society of Analytical Sciences. All rights reserved.